About UsDepartmentsInternational Symposium on Traditional Medicine in ToyamaMuseum of Materia Medica

Division of Natural Products Chemistry, Department of Medicinal Resources


TEL: 076-434-7625; FAX: 076-434-5059
[English] http://www.inm.u-toyama.ac.jp/en/departments/02_napc.html
[Japanese] http://www.inm.u-toyama.ac.jp/jp/departments/02_napc.html
[Website of the Division] http://www.inm.u-toyama.ac.jp/napc/index.html

Professor Hiroyuki Morita, Ph.D.
Professor
Hiroyuki Morita, Ph.D.
Associate Prof. Takuya Itoh
Associate Professor
Takuya Ito, Ph.D.

Assistant Prof. WONG CHIN PIOW
Assistant Professor
Wong Chin Piow, Ph.D.


Research Outline

The major aim in our division is to clarify the detailed inhibition mechanism of the naturally occurring bioactive substances in natural medicines with the crystal and solution NMR structure analyses of the target proteins complexed with the substances, and to discover novel bioactive substances from natural medicines. Further, to elucidate the biosynthesis of the bioactive substances from natural medicines, and to produce novel bioactive substances, we also focus on the functional analysis and engineering of novel biosynthetic enzymes. A multidisciplinary methods such as synthesis of the enzyme substrates, analysis/isolation/structure elucidation of the bioactive substances from natural medicines and enzyme reaction products with HPLC, NMR and MS/MS etc, molecular cloning of the biosynthetic enzymes, expression/purification/crystallization of the enzymes, and crystal and solution NMR structure analyses of the enzymes are employed for our researches.



Basic research for naturally occurring bioactive substances in traditional natural medicines
1.

Discovery of naturally occurring anti-HIV agents that inhibit HIV-1 Vpr protein from plants, microorganisms, and marine organisms and analysis of their inhibition mechanisms.

2.

Studies on antibacterial agents from plants, microorganisms, and marine organisms.

3.

Discovery of novel anticancer agents from plants, microorganisms, and marine organisms and synthesis of their derivatives.

4.

Complex structure analyses between protein and natural product for developing novel medicines.

5. Investigation of Asia’s natural resources not fully utilized.
   
Studies on biosynthesis of bioactive substances in traditional natural medicines
1.

Crystal structure analyses and structure-based engineering of plant-specific polyketide synthases.

2.

Structural basis for indole prenyltransferase from microorganisms.

3.

Heterologous expression and functional analysis of novel enzymes involved in the biosynthesis of bioactive substances.

   
   
【keywords】
  Natural resource not fully utilized, Medicinal plant, Marine organism, Microorganism, Active secondary metabolite, Structure analysis of natural products, Anti-cancer, Anti-microbe, Anti-virus, Biosynthesis, Enzyme engineering, Genetic engineering, Structure analysis of Proteins

pic_03 PIC