About UsDepartmentsInternational Symposium on Traditional Medicine in ToyamaMuseum of Materia Medica

Division of Medicinal Pharmacology, Department of Bioscience

TEL:076-434-7610; Fax:076-434-5056
[English] http://www.inm.u-toyama.ac.jp/en/departments/04_mp.html
[Japanese] http://www.inm.u-toyama.ac.jp/jp/departments/04_mp.html
[Website of the Division] http://www.inm.u-toyama.ac.jp/shiken/index-j.html

Professor Kinzo Matsumoto
Kinzo Matsumoto, Ph.D.
Associate Professor Michihisa Tohda
Associate Professor
Michihisa Tohda, Ph. D.

Assistant Professor Hironori Fujiwara
Assistant Professor
Hironori Fujiwara, Ph. D.

Research Outline

In this laboratory, we investigate pharmacological effects and underlying mechanisms of traditional medicines which particularly target cognitive and neuropsychiatric disorders. Our studies aim 1) to clarify pathophysiology and onset mechanisms underlying cognitive and neuropsychiatric disorders, 2) to elucidate quantitatively the pharmacological effects of traditional medicines using model systems for the disorders, and 3) to identify the active components of traditional medicines, molecular mechanisms of their actions, and endogenous factors mediating the actions.

I. Experimental studies on pathophysiology, onset mechanisms, and prevention/therapy of neuropsychiatric disorders in animal models
1) Pharmacological and neurobiological analysis of behavioral abnormalities caused in animal models of neuropsychiatric disorders such as social isolation rearing and chronic mild stress.
2) Elucidation of neurobiological activities of traditional medicines with preventive/therapeutic potentials for neuropsychiatric disorders in the models.
3) Experimental studies on neurosteroidal regulation of developmental disorders.

II. Neuropharmacological studies on psychotropic actions of natural medicine materials
1) Elucidation of traditional medicine as anti-dementia/neuroprotective drugs, and clarification of the mechanisms underlying their actions.
2) Molecular pharmacological and electrophysiological analysis of the actions of psychotropic drugs using in vitro models of neurological disorders.

III. Molecular biological studies on the actions of psychotropic drugs and traditional medicines
1) Studies to identify the depression-related intrinsic factors and to develop antidepressants with novel mechanisms, on the basis of the Wakan-yaku theories such as Yin-Yang and 5-Elememts.
2) Analysis of endogenous and exogenous factors mediating anti-dementia or anti-stress effects of traditional medicines.
  Sporadic dementia, Epigenetic neuropsychiatric disorder, Stress, Wakan-yaku theory