The major aim in our division is to clarify the inhibition mechanism of the naturally occurring bioactive substances in natural medicines with the crystal and solution NMR structure analyses of the target proteins complexed with the substances, and to discover novel bioactive substances from natural medicines.
Further, to elucidate the biosynthesis of the bioactive substances from natural medicines, and to produce novel bioactive substances, we also focus the functional analysis and engineering of novel biosynthetic enzymes.

A multidisciplinary methods such as synthesis of the enzyme substrates, analysis, isolation, structure elucidation of the bioactive substances from natural medicines and enzyme reaction products with HPLC, NMR and MS/MS etc, molecular cloning of the biosynthetic enzymes, crystallization of the enzymes, and crystal and solution NMR structure analyses of the enzymes are employed for our researches.

If you have any questions, please let Prof. Morita know.


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Divison of Natural Product Chemistry, Institute of Natural Medicine, University of Toyama.
2630 Sugitani, Toyama-shi, Toyama, 930-0194, Japan. TEL/FAX:+81-76-434-7625