2017 2016 2015 2014 2013 2012 2011 2010 2009


1) Awale S., Tawila AM., Dibwe DF., Ueda JY., Sun S., Athikomkulchai S., Balachandran C., Saiki I., Matsumoto K., Esumi H.: Highly oxygenated antiausterity agents from the leaves of Uvaria dac. Bioorg. Med. Chem. Lett., 27(9): 1967-1971, 2017. doi: 10.1016/j.bmcl.2017.03.021. [Abstract]
2) Fujiwara H., Han Y., Ebihara K., Awale S., Araki R., Yabe T., Matsumoto K.: Daily administration of yokukansan and keishito prevents social isolation-induced behavioral abnormalities and down-regulation of phosphorylation of neuroplasticity-related signaling molecules in mice. BMC Complement. Altern. Med., 17: 195, 2017. doi: 10.1186/s12906-017-1710-7. [Abstract]
3) Ebihara K., Fujiwara H., Awale S., Dibwe DF., Araki R., Yabe T., Matsumto K.: Decrease in endogenous brain allopregnanolone induces autism spectrum disorder (ASD)-like behavior in mice: a novel animal model of ASD. Behav. Brain. Res., 334: 6-15, 2017. doi: 10.1016/j.bbr.2017.07.019. [Abstract]
4) Dibwe DF., Sun S., Ueda JY., Balachandran C., Matsumoto K., Awale S.: Discovery of potential antiausterity agents from the Japanese cypress Chamaecyparis obtusa. Bioorg. Med. Chem. Lett., 27: 4898-4903, 2017. doi: 10.1016/j.bmcl.2017.09.034. [Abstract]
5) Sasaki-Hamada S., Suzuki A., Sanai E., Matsumoto K., Oka JI.: Neuroprotection by chotosan, a Kampo formula, against glutamate excitotoxicity involves the inhibition of GluN2B-, but not GluN2A-containing NMDA receptor-mediated responses in primary cultured cortical neurons. J. Pharmacol. Sci., 135: 134-137, 2017. doi: 10.1016/j.jphs.2017.10.009. [Abstract]
6) Tohda C., Tohda M.: Extracellular cathepsin L stimulates axonal growth in neurons. BMC Res. Notes., 10(1): 613, 2017. doi: 10.1186/s13104-017-2940-y. [Abstract]
7) Tohda M.: Novel RNA editing sites of 5-HT2C receptor encoding the third intracellular loop domain in undifferentiated NG108-15 cells. Ann. Pharmacol. Pharmaceu., 2(26): 1136, 2017.[Abstract]
8) Fujiwara H., Tsushima R., Okada R., Awale S., Araki R., Yabe T., Matsumoto K.: Sansoninto, a traditional herbal medicine, ameliorates behavioral abnormalities and down-regulation of early growth response-1 expression in mice exposed to social isolation stress. J. Tradit. Complement. Med., 8(1):81-88, 2018. doi: 10.1016/j.jtcme.2017.03.004.[Abstract]
9) Tohda M.: Possible interaction of serotonin 2C receptor mRNA editing at C-site with expression of microtubule-associated protein 2 and neurite outgrowth in rat cultured cortical cells. MOJ Curr Res & Rev., 2018;1(1): 00004, 2018. DOI: 10.15406/mojcrr.2018.01.00004 [Abstract]


1) Nguyen HX., Nguyen NT., Dang PH., Thi PH., Nguyen MTT., Can MV., Dibwe D-F., Uedad J-Y., Matsumoto K., Awale S: A New Cassane-type Diterpene from the Seed of Caesalpinia sappan. Natural Product Comm., 11: 723-724, 2016. [Abstract]
2) Takito J., Ota M., Oba C., Fujiwara H., Murata K., Yamaguchi K., Uozumi N., Nakamura M., Inomata H., Ohizumi Y.: Limonene Enhances the cAMP Response Element (CRE)-Dependent Transcriptional Activity Activated via Adenosine A2A Receptor in a Neural-Crest Derived Cell Line, PC-12. Planta Med. Int. Open, 3(3): e60–e63, 2016. doi: http://dx.doi.org/10.1055/s-0042-118778[Abstract]
3) Oba C., Ota M., Nomura K., Fujiwara H., Takito J., Sato Y., Ohizumi Y., Inomata H.: Extraction of nobiletin from Citrus Unshiu peels by supercritical fluid and its CRE-mediated transcriptional activity. Phytomedicine, 27:33-38, 2017. doi: http://dx.doi.org/10.1016/j.phymed.2017.01.014 [Abstract]
4) Sasaki-Hamada S., Suzuki A., Ueda Y., Matsumoto K., Oka JI.: Serotonergic and dopaminergic systems are implicated in antidepressant-like effects of chotosan, a Kampo formula, in mice. J Pharmacol Sci. , 133(2): 110-113, 2017. doi: 10.1016/j.jphs.2017.01.002. [Abstract]


1) Niu Y., Li F., Inada C., Watanabe S., Fujiwara H., Tanaka K., Sasaki-Hamada S., Oka J-I., Matsumoto K.: Chemical profiling with HPLC-FTMS of exogenous and endogenous chemicals susceptible to the administration of chotosan in an animal model of type 2 diabetes. J. Pharm. Biomed. Ana., 104: 21-30, 2015. [Abstract]
2) Watari H., Shigyo M., Tanabe N., Tohda M., Cho K.H., Kyung P.S., Jung W.S., Shimada Y., Shibahara N., Kuboyama T., Tohda C.: Comparing the effects of kamikihito in Japan and kami-guibi-tang in Korea on memory enhancement: working towards the development of a global study. Phytother. Res., 29: 351-356, 2015. [Abstract]
3) Le T.X., Pham T.N.H., Nguyen V.T., Nguyen M.K., Tanaka K., Fujiwara H., Matsumoto K.: Protective effects of Bacopa monnieri on ischemia-induced cognitive deficits in mice: the possible contribution of bacopaside I and underlying mechanism. J. Ethnopharmacol., 164:37-45, 2015. [Abstract]
4) Lê T.X., Nguyễn H.A., Phạm T.N.H, Nguyễn V.T., Nguyễn T.P., Matsumoto K.: Antidepressant-like effect of Ocimum sanctum in olfactory bulbectomized mice. Journal of Medicinal Materials, Hanoi, 20: 311-316, 2015.[Abstract]
5) Okada R., Fujiwara H., Mizuki D., Araki R, Yabe T., Matsumoto K.: Involvement of dopaminergic and cholinergic systems in social isolation-induced deficits in social affiliation and conditional fear memory in mice. Neuroscience, 299: 134-145, 2015. [Abstract]
6) Rojsanga P., Sithisarn P., Tanaka K., Mizuki D., Matsumoto K.: Thunbergia laurifolia extract ameliorates cognitive and emotional deficits in olfactolectomized mice. Pharmaceutical Biology, 53(8):1141-1148, 2015. [Abstract]
7) Araki R., Nishida S., Hiraki Y., Matsumoto K., Yabe T.: DNA methylation of the GC box in the promoter region suppresses transcription of srd5a1 in the prefrontal cortex. Neurosci. Lett., 606:135-139, 2015. [Abstract]
8) Yamashita S., Kiko T., Fujiwara H., Hashimoto M., Nakagawa K., Kinoshita M., Furukawa K., Arai H., Miyazawa T.: Alterations in the Levels of Amyloid-β, Phospholipid Hydroperoxide, and Plasmalogen in the Blood of Patients with Alzheimer's Disease: Possible Interactions between Amyloid-β and These Lipids. J. Alzheimers Dis., 50: 527-537, 2015.[Abstract]
9) Araki R., Hiraki Y., Nishida S., Kuramoto N., Matsumoto K., Yabe T.: Epigenetic regulation of dorsal raphe GABAB1a associated with isolation-induced abnormal responses to social stimulation in mice. Neuropharmacology., 101: 1-12, 2016. [Abstract]
10) Araki R., Nishida S., Hiraki Y., Li F., Matsumoto K., Yabe T.: Kamikihito Ameliorates Lipopolysaccharide-Induced Sickness Behavior via Attenuating Neural Activation, but Not Inflammation, in the Hypothalamic Paraventricular Nucleus and Central Nucleus of the Amygdala in Mice. Biol. Pharm. Bull., 39: 289-94, 2016. [Abstract]


1) Mizuki D., Qi Z., Tanaka K., Fujiwara H., Ishikawa T., Higuchi Y., Matsumoto K.: Butea superba-induced amelioration of cognitive and emotional deficits in olfactory bulbectomized mice and putative mechanisms underlying its actions. J Pharmacol Sci., 124:457-467, 2014. [Abstract]
2) Thiratmatrakul S., Yenjai C., Waiwut P., Vajragupta O., Reubroycharoen P., Tohda M., Boonyarat C.: Synthesis, biological evaluation and molecular modeling study of novel tacrine-carbazole hybrids as potential multifunctional agents for the treatment of Alzheimer’s disease. Eur J Med Chem., 75:21-30, 2014. [Abstract]
3) Okada R., Matsumoto K., Tsushima R., Fujiwara H., Tsuneyama K.: Social isolation stress-induced fear memory deficit is mediated by down-regulated neuro-signaling system and Egr-1 expression in the brain. Neurochem Res., 39:875-882, 2014. [Abstract]
4) Fujiwara H., Kimura J., Sakamoto M., Yokosuka A., Mimaki Y., Murata K., Yamaguchi K., Ohizumi Y.: Nobiletin, a flavone from Citrus depressa, induces gene expression and increases the protein level and activity of neprilysin in SK-N-SH cells. Can J Physiol Pharmacol., 92:351-355, 2014. [Abstract]
5) Inada C., Niu Y., Matsumoto K., Le X.T., Fujiwara H.: Possible involvement of VEGF signaling system in rescuing effect of endogenous acetylcholine on NMDA-induced long-lasting hippocampal cell damage in organotypic hippocampal slice cultures. Neurochem Int., 75:39-47, 2014. [Abstract]
6) Monthakantirat O., Sukano W., Umehara K., Noguchi H., Chulikhit Y., Matsumoto K.: Effect of miroestrol on ovariectomy-induced cognitive impairment and lipid peroxidation in mouse brain. Phytomedicine., 21:1249-1255, 2014. [Abstract]
7) Mizuki D., Matsumoto K., Tanaka K., Le X.T., Fujiwara H., Ishikawa T., Higuchi Y.: Antidepressant-like effect of Butea superba in mice exposed to chronic mild stress and its possible mechanism of action. J Ethnopharmacol., 156:16-25, 2014. [Abstract]
8) Watari H., Shigyo M., Tanabe N., Tohda M., Cho K.H., Kyung P.S., Jung W.S., Shimada Y., Shibahara N., Kuboyama T., Tohda C.: Comparing the Effects of Kamikihito in Japan and Kami-Guibi-Tang in Korea on Memory Enhancement: Working Towards the Development of a Global Study. Phytother Res., DOI: 10.1002/ptr.5250, 2014. [Abstract]
9) Tohda M.: Changes in the expression of BNIP-3 and other neuronal factors during the cultivation period of primary cultured rat cerebral cortical neurons and an assessment of each factor’s functions. Cell Signalling and Trafficking, DOI: 10.7243/2054-1481-2-1, 2014. [Abstract]


1) Le X.T., Pham H.T., Do P.T., Fujiwara H., Tanaka K., Li F., Van Nguyen T., Nguyen K.M., Matsumoto K.: Bacopa monnieri ameliorates memory deficits in olfactory bulbectomized mice: possible involvement of glutamatergic and cholinergic systems. Neurochem. Res., 38: 2201-2215, 2013. [Abstract]
2) Nemoto K., Ikeda A., Yoshida C., Kimura J., Mori J., Fujiwara H., Yokosuka A., Mimaki Y., Ohizumi Y., Degawa M.: Characteristics of nobiletin-mediated alteration of gene expression in cultured cell lines. Biochem. Biophys. Res. Commun., 431: 530-534, 2013. [Abstract]
3) Ouchi H., Ono K., Murakami Y., Matsumoto K.: Social isolation induces deficit of latent learning performance in mice: a putative animal model of attention deficit/hyperactivity disorder. Behav. Brain Res., 238: 46-153, 2013. [Abstract]
4) Inada C., Thi Le X., Tsuneyama K., Fujiwara H., Miyata T., Matsumoto K.: Endogenous acetylcholine rescues NMDA-induced long-lasting hippocampal cell damage via stimulation of muscarinic M1 receptors: elucidation using organic hippocampal slice cultures. Eur. J. Pharmacol., 699: 150-159, 2013. [Abstract]
5) Sithisarn P., Rojsanga P., Jarikasem S., Tanaka K., Matsumoto K.: Ameliorative Effects of Acanthopanax trifoliatus on cognitive and emotional deficits in olfactory bulbectomized mice: an animal model of depression and cognitive deficits. Evid. Based Complement. Alternat. Med., 2013: 701956, 2013. [Abstract]
6) Tohda M., Mingmalairak S.: Evidence of antidepressive effects of a Wakan-yaku, Hochuekkito, in depression model mice with learned-helplessness behavior. Evid. Based Complement. Alternat. Med. 2013: 319073, 2013. [Abstract]
7) Sasaki-Hamada S., Tamaki K., Otsuka H., Ueno T., Sacai H., Niu Y., Matsumoto K., Oka J.: Chotosan, a Kampo formula, ameliorates hippocampal LTD and cognitive deficits in juvenile-onset diabetes rats. J Pharmacol. Sci., 2013.


1) Matsumoto K., Ono K., Ouchi H., Tsushima R.-H., and Murakami Y.: Social isolation stress down-regulates cortical early growth response 1 (Egr-1) expression in mice. Neurosci. Res., 73: 257-262, 2012. [Abstract]
2) Rojsanga P., Boonyarat C., Utsintong M., Nemecz Á., Yamauchi J.G., Talley T.T., Olson A.J., Matsumoto K., and Vajragupta O.: The effect of crebanine on memory and cognition impairment via the alpha-7 nicotinic acetylcholine receptor. Life Sci., 91:107-114, 2012.
3) Zhao Q., Niu Y., Matsumoto K., Tsuneyama K., Tanaka K., Miyata T., and Yokozawa T.: Chotosan ameliorates cognitive and emotional deficits in an animal model of type 2 diabetes: possible involvement of cholinergic and VEGF/PDGF mechanisms in the brain. BMC Comp. Alt. Med., 12: 188, 2012. [Abstract]
4) Yamaguchi K., Fujiwara H., Sakamoto M., Murata K., Hitomi N., Li Z.-G., He. S., and Ohizumi Y.: The property of active substance from royal jelly in CRE-mediated transcriptional activity. Pharmacometrics, 82: 17-20, 2012.


1) Noh J.S., Park C.H., Kim H.Y., Zhao Q., Yamabe N., Matsumoto K., and Yokozawa T.: Chinese prescription Kangen-karyu prevents dyslipidaemia and oxidative stress in mouse model of type 2 diabetes. J. Pharm. Pharmacol. 63, 111-9; 2011. [Abstract]
2) Yamada M., Hayashida M., Zhao Q., Shibahara N., Tanaka K., Miyata T., and Matsumoto K.: Ameliorative effects of yokukansan on learning and memory deficits in olfactory bulbectomized mice. J. Ethnopharmacol. 135, 737-46; 2011. [Abstract]
3) Zhao Q., Yokozawa T., Tsuneyama T., Tanaka K., Miyata T., Shibahara N., Matsumoto K.: Chotosan-induced improvement of cognitive deficits in senescence-accelerated mouse (SAMP8) involves normalization of angiogenic/neurotrophic factors and neuroplasticity systems in the brain. Chin. Med. 6, 33 (on line); 2011. [Abstract]
4) Utsintong M., Rojsanga P., Ho K.Y., Talley T.T., Olson A.J., Matsumoto K., and Vajragupta O.: Virtual Screening against Acetylcholine Binding Protein. Journal of Biomolecular Screening. PMID: 21956172; 2011. [Abstract]
5) Zhao Q., Matsumoto K., Tsuneyama K., Tanaka K., Li F., Shibahara N., Miyata T., and Yokozawa T.: Diabetes-induced central cholinergic neuronal loss and cognitive deficit are attenuated by tacrine and a Chinese herbal prescription, kangen-karyu: elucidation in type 2 diabetes db/db mice. J. Pharmacol. Sci. 117, 230-42; 2011. [Abstract]
6) Park C.H., Noh J.H., Kim J.H., Tanaka T., Zhao Q., Matsumoto K., Shibahara N., and Yokozawa T.: Evaluation of morroniside, iridoid glycoside from Corni Fructus, on diabetes-induced alterations such as oxidative stress, inflammation, and apoptosis in the liver of type 2 diabetic db/db mice. Biol. Pharm. Bull. 34, 1559-65; 2011. [Abstract]
7) Sukma M., Tohda M., Suksamran S., and Tantisira B.: γ-Mangostin increases serotonin 2A/2C, muscarinic, histamine and bradykinin receptor mRNA expression. J. Ethnopharmacol. 135, 450-4; 2011. [Abstract]
8) Hang P.T.N., Phuong D.T., Phuong N.T., Xuyen P.T., Ha Q.T.L., Khoi N.M., and Tohda M.: Establishment of the cell culture model to study anti-depressant effect on primary culture cortical cells and NG108-15 cell line. J. Medicinal Materials-Hanoi 16, 277-81; 2011. [Abstract]


1) Tohda M., Mingmalairak S., Murakami Y., and Matsumoto K.: Enhanced expression of BCL2/adenovirus EIB 19-kDa-interacting protein 3 mRNA, a candidate for intrinsic depression-related factor, and effects of imipramine in the frontal cortex of stressed mice. Biol. Pham. Bull. 33, 53-7; 2010. [Abstract]
2) Pham N.T., Tohda M., Tezuka Y., and Matsumoto K.: Influence of an adenosine deaminase inhibitor, erythro-9-(2-hydroxy-3-nonyl) adenine hydrochloride, on 5-HT2CR mRNA editing in primary cultured cortical cells. Biol. Pham. Bull. 33, 527-9; 2010. [Abstract]
3) Yamabe N., Kim H.Y., Kang K.S., Zhao Q., Matsumoto K., and Yokozawa T.: Effect of Chinese prescription Kangen-karyu on lipid metabolism in type 2 diabetic db/db mice. J Ethnopharmacol. 129, 299-305; 2010. [Abstract]
4) Mingmalairak S., Tohda M., Murakami Y., and Matsumoto K.: Possible involvement of signal transducers and activators of transcription 3 system on depression in the model mice brain. Biol Pharm Bull. 33, 636-40; 2010. [Abstract]
5) Zhao Q., Yokozawa T., Yamabe N., Tsuneyama K., Li X., and Matsumoto K.: Kangen-karyu improves memory deficit caused by aging through normalization of neuro-plasticity-related signaling system and VEGF system in the brain. J Ethnopharmacol. 131, 377-85; 2010. [Abstract]
6) Tohda M., Hang P.N.T., Kobayashi N., and Matsumoto K.: Serotonin 2C receptor (5-HT2CR) mRNA editing-induced down-regulation of 5-HT2CR function in Xenopus oocytes: the significance of site C editing. J Pharmacol Sci. 113, 362-7; 2010. [Abstract]


1) Cui H.S., Matsumoto K., Hori H., Zhao Q. and Obi R.: Berberine exerts neuroprotective actions against in vitro ischemia-induced neuronal cell damage in organotypic hippocampal slice cultures: involvement of B-cell lymphoma 2 phosphorylation suppression. Biol. Pham. Bull. 32, 79-85; 2009.[Abstract]
2) Tohda M., Hang P.N.T. and Matsumoto K.: Developmental changes in serotonin 2C receptor mRNA editing in the rat cerebral cortex and primary cultured cortical neurons. Biol. Pham. Bull. 32, 289-92; 2009.[Abstract]
3) Yokozawa T., Lee Y.A., Zhao Q., Matsumoto K. and Cho E.J.: Persimmon oligomeric proanthocyanidins extend life span of senescence-accelerated mice. J. Med. Food. 12, 1199-205; 2009.[Abstract]