2017 2016 2015 2014 2013 2012 2011 2010 2009


1) Tohda C., Tohda M. : Extracellular cathepsin L stimulates axonal growth in neurons. BMC Res Note., 10(1): 613, 2017. doi: 10.1186/s13104-017-2940-y. [Abstract]
2) Kuboyama T., Hirotsu K., Arai T., Yamasaki H., Tohda C. : Polygalae Radix extract prevents axonal degeneration and memory deficits in a transgenic mouse model of Alzheimer’s disease. Front Pharmacol., 8: 805, 2017. doi: 10.3389/fphar.2017.00805. [Abstract]
3) Tohda C., Yang X., Matsui M., Inada Y., Kadomoto E., Nakada S., Watari H., Shibahara N. : Diosgenin-Rich Yam Extract Enhances Cognitive Function: A Placebo-Controlled, Randomized, Double-Blind, Crossover Study of Healthy Adults. Nutrients, 9(10), 1160, 2017. doi: 10.3390/nu9101160. [Abstract]
4) Kobayashi R., Tohda C. : Extracellular Cytosolic Aspartate Aminotransferase Promotes Axonal Growth and Object Recognition Memory. Neurochem Res., 42(12): 3465-3473, 2017. doi: 10.1007/s11064-017-2394-6. [Abstract]
5) Kuboyama T., Wahane S., Huang Y., Zhou X., Wong J. K., Koemeter-Cox A., Martini M., Friedel R. H., Zou H. : HDAC3 inhibition ameliorates spinal cord injury by immunomodulation. Sci Rep., 7(1): 8641, 2017. doi: 10.1038/s41598-017-08535-4. [Abstract]
6) Kogure C., Tohda C. : Human placenta extract ameliorates memory dysfunction and dendritic atrophy in a 5XFAD mouse model of Alzheimer’s disease. Traditional & Kampo Medicine, 4(2): 94-104, 2017. doi: 10.1002/tkm2.1075. [Abstract]
7) Yang Z., Kuboyama T., Tohda C. : A systematic strategy for discovering a therapeutic drug for Alzheimer’s disease and its target molecule. Front Pharmacol., 8: 340, 2017. doi: 10.3389/fphar.2017.00340. [Abstract]
8) Yang X., Tohda C.: Heat Shock Cognate 70 Inhibitor, VER-155008, Reduces Memory Deficits and Axonal Degeneration in a Mouse Model of Alzheimer’s Disease. Front Pharmacol., 9: 48, 2018. doi: 10.3389/fphar.2018.00048. [Abstract]
9) Sakamoto I., Ueyama T., Hayashibe M., Nakamura T., Mohri H., Kiyonari H., Shigyo M., Tohda C., Saito N. : Roles of Cdc42 and Rac in Bergmann glia during cerebellar corticogenesis. Exp Neurol., 302:57-67, 2018. pii: S0014-4886(17)30332-1, 2017. doi: 10.1016/j.expneurol.2017.12.003. [Abstract]


1) Shigyo M., Tohda C.: Extracellular vimentin is a novel axonal growth facilitator for functional recovery in spinal cordinjured mice. Scientific Reports, 6:28293, 2016. doi:10.1038/srep28293. [Abstract]
2) Ge Y.W., Tohda C., Zhu S., He Y.M., Yoshimatsu K., Komatsu K.: Effects of oleanane-type triterpene saponins from the leaves of Eleutherococcus senticosus in an axonal outgrowth assay. J. Nat. Prod., 79(7):1834-1841, 2016. doi: 10.1021/acs.jnatprod.6b00329. [Abstract]
3) Ishii T., Ueyama T., Shigyo M., Kohta M., Kondoh T., Uebi T., Kuboyama T., Gutmann D.H., Aiba A., Kohmura E., Tohda C., Saito N.: A Novel Rac1-GSPT1 signaling pathway controls astrogliosis following central nervous system injury. J. Biol. Chem., 292(4):1240-1250, 2017. doi: 10.1074/jbc.M116.748871. [Abstract]


1) Sugimoto K., Yajima H., Hayashi Y., Minato D., Terasaki S., Tohda C., Matsuya Y.: Synthesis of Denosomin-Vitamin D3 Hybrids and Evaluation of their Anti-Alzheimer’s Disease Activities. Organic Lett., 17(23): 5910-5913, 2015. [Abstract]
2) Watari H., Shimada Y., Tohda C.: Cytosolic aspartate aminotransferase, a direct binding protein of kamikihito, regulates axon growth. Traditional Kampo Medicine, in press, 2015. [Abstract]
3) Yang Z., Kuboyama T., Kazuma K., Konno K., Tohda C.: Active constituents from Drynaria fortune Rhizomes on the attenuation of Aβ25-35-induced axonal atrophy. J Natural Products, 78(9): 2297-2300, 2015. [Abstract]
4) Watari H., Shigyo M., Tanabe N., Tohda M., Cho K-H., Kyung P-S., Jung W-S., Shimada Y., Shibahara N., Kuboyama T., Tohda C.: Comparing the effects of kamikihito in Japan and kami-guibi-tang in Korea on memory enhancement: working toward the development of a global study. Phytother Res., 29(3): 351-356, 2015. [Abstract]
5) Shigyo M., Kuboyama T., Sawai Y., Tada-Umezaki M., Tohda C.: Extracellular vimentin interacts with insulin-like growth factor 1 receptor to promote axonal growth. Scientific Reports, 5: 12055, 2015. [Abstract]
6) Kuboyama T., Lee Y-A., Nishiko H., Tohda C.: Inhibition of clathrin-mediated endocytosis prevents amyloid β-induced axonal damage. Neurobiology of Aging, 36(5): 1808-1819, 2015.[Abstract]


1) Zhang H-Y., Yamakawa Y., Matsuya Y., Toyooka N., Tohda C., Awale S., Li F., Kadota S., Tezuka Y.: Synthesis of long-chain fatty acid derivatives as a novel anti-Alzheimer's agent.  Bioorganic & Medicinal Chemistry Letters. 24(2):604-608, 2014. [Abstract]
2) Watari H., Shimada Y., Tohda C.: New treatment for Alzheimer’s disease, kamikihito, reverses amyloid-ß-induced progression of tau phosphorylation and axonal atrophy. Evidence-Based Complementary and Alternative Medicine. Volume 2014: Article ID 706487, 2014. [Abstract]
3) Shigyo M., Tanabe N., Kuboyama T., Choi S-H., Tohda C.: New reliable scoring system, Toyama Mouse Score, to evaluate locomotor function following spinal cord injury in mice. BMC Research Note. 3;7:332, 2014. [Abstract]
4) Watari H., Shigyo M., Tanabe N., Tohda M., Cho K-H., Kyung P-S., Jung W-S., Shimada Y., Shibahara N., Kuboyama T., Tohda C.: Comparing the effects of kamikihito in Japan and kami-guibi-tang in Korea on memory enhancement: working toward the development of a global study. Phytother Res. Epub ahead of print, 2014. [Abstract]


1) Tohda C., Lee Y.A., Goto Y., Nemere I.: Diosgenin-induced cognitive enhancement in normal mice is mediated by 1,25D3-MARRS. Sci Rep. 3: 3395, 2013. [Abstract]
2) Kuboyama T., Luo X., Park K., Blackmore M.G., Tojima T., Tohda C., Bixby J.L., Lemmon V.P., Kamiguchi H.: Paxillin phosphorylation counteracts proteoglycan-mediated inhibition of axon regeneration. Exp Neurol. 248: 157-169, 2013. [Abstract]
3) Sugimoto K., Tamura K., Tohda C., Toyooka N., Nemoto H., Matsuya Y.: Structure-activity-relationship studies on dihydrofuran-fused perhydrophenanthrenes as an anti-Alzheimer's disease agent. Bioorg Med Chem. 21(15): 4459-4471, 2013. [Abstract]
4) Teshigawara K., Kuboyama T., Shigyo M., Nagata A., Sugimoto K., Matsuya Y., Tohda C.: A novel compound, denosomin, ameliorates spinal cord injury via axonal growth associated with astrocyte-secreted vimentin. Br J Pharmacol. 168(4): 903-919, 2013. [Abstract]


1) Tohda C., Urano T., Umezaki M., Nemere I., Kuboyama T.: Diosgenin is an exogenous activator of 1,25D3-MARRS/Pdia3/ERp57 and improves Alzheimer’s disease pathologies in 5XFAD mice. Sci. Rep. 2, 535; DOI: 10.1038/srep00535, 2012. [Abstract]
2) Tohda C., Nagata A.: Epimedium koreanum extract and its constituent icariin improve motor dysfunction in spinal cord injury. Evidence Based Complementary and Alternative Medicine 2012:731208, 2012. [Abstract]
3) Wang X.-H., Zhu H., Konno K., Tohda C., Kazuma K., Kuboyama T., Miyanaga S.: Screening of fractions from some Chinese herbs for spinal cord injury. Chinese Journal of Experimental Traditional Medical Formulae, 18(12):246-248, 2012. [Abstract]
4) Sugimoto K., Tamura K., Ohta N., Tohda C., Toyooka N., Nemoto H., Matsuya Y.: Synthesis of dihydrofuran-fused perhydrophenanthrenes having a phenolic hydroxyl group as a novel anti-Alzheimer's disease agent. Bioorganic & Medicinal Chemistry Letters, 22(1):449-452, 2012. [Abstract]


1) Bai Y., Tohda C., Zhu S., Hattori M., Komatsu K.: Active components from Siberian ginseng (Eleutherococcus senticosus) for protection of amyloid β(25-35)-induced neuritic atrophy in cultured rat cortical neurons. J. Nat. Med. 65: 417-423, 2011.[Abstract]
2) Joyashiki E., Matsuya Y., Tohda C.: Sominone improves memory impairments and increases axonal density in Alzheimer's disease model mice, 5XFAD. Int. J. Neurosci. 121:.181-190, 2011.[Abstract]
3) Tohda C., Nakada R., Urano T., Okonogi A., Kuboyama T.: Kamikihi-to (KKT) Rescues Axonal and Synaptic Degeneration Associated with Memory Impairment in a Mouse Model of Alzheimer's Disease, 5XFAD. Int. J. Neurosci. 121: 641-648, 2011.[Abstract]


1) Urano T., Tohda C.: Icariin improved memory impairment in Alzheimer's disease model mice (5XFAD) and attenuates amyloid β-induced neurite atrophy. Phytother. Res., 24(11):1658-63, 2010.[Abstract]
2) Prangsaengtong O., Koizumi K., Senda K., Urano T., Nagata A., Sakurai H., Tohda C., Saiki I.: Methanol extract of Polygonati Rhizoma enhances the tube formation of rat lymphatic endotherial cells. J. Trad. Med. 27:59-65, 2010.


1) Tohda C., Joyashiki E.: Sominone enhances neurite outgrowth and spatial memory mediated by the neurotrophic factor receptor, RET. Br. J. Pharmacol., 157: 1427-1440, 2009.
2) Matsuya Y., Yamakawa Y., Tohda C., Teshigawara K., Yamada M. and Nemoto H.: Synthesis of Sominone and Its Derivatives Based on RCM Strategy: Discovery of A Novel Anti-Alzheimer's Disease Medicine Candidate "Denosomin". Org. Lett. 11: 3970-3973, 2009.
3) Awale S., Tohda C., Tezuka Y., Miyazaki M., Kadota S.: Protective effects of Rosa damascena and its active constituent on Aβ(25-35)-induced neuritic atrophy. Evid. Based Complement. Alternat. Med., Epub ahead of print, 2009.
4) Tohda C., Nakanishi R., and Kadowaki M.: Hyperactivity, memory deficit and anxiety-related behaviors in mice lacking the p85α subunit of phosphoinositide-3 kinase. Brain & Develop., 31: 69-74, 2009.