2016 2015 2014 2013 2012 2011 2010 2009

2016

1) Prangsaengtong O., Athikomkulchai S., Xu J., Koizumi K., Inujima A., Shibahara N., Shimada Y., Tadtong S., Awale S.: Chrysin Inhibits Lymphangiogenesis in Vitro. Biol Pharm Bull., 39: 466-472, 2016. doi: 10.1248/bpb.b15-00543. [Abstract]
2) Jeong S., Kimura M., Fujimoto M., Nogami T., Watari H., Hikiami H., Shimada Y.: The traditional Japanese formulas tokishakuyakusan and ogikenchuto suppress dermal sclerosis in bleomycin-induced murine scleroderma. Tradit Kampo Med., 3: 112-119, 2016. [Abstract]
3) Ma Y., Fujimoto M., Watari H., Kimura M., Shimada Y.: The renoprotective effect of shichimotsukokato on hypertension-induced renal dysfunction in spontaneously hypertensive rats. J Nat Med., 70: 152-162, 2016. doi: 10.1007/s11418-015-0945-1.[Abstract]
4) Matsuo K., Koizumi K., Fujita M., Morikawa T., Jo M., Shibahara N., Saiki I., Yoshie O., Nakayama T.: Efficient Use of a Crude Drug/Herb Library Reveals Ephedra Herb as a Specific Antagonist for TH2-Specific Chemokine Receptors CCR3, CCR4, and CCR8. Front Cell Dev Biol., 4: 54, 2016. doi: 10.3389/fcell.2016.00054. [Abstract]


2015

1) Refaat A., Aminullah, Zhou Y., Kawanishi M., Tomaru R., Abdelhamed S., Shin M.S., Koizumi K., Yokoyama S., Saiki I., Sakurai H.: Role of tyrosine kinase-independent phosphorylation of EGFR with activating mutation in cisplatin-treated lung cancer cells. Biochem Biophys Res Commun., 458(4): 856-861, 2015. [Abstract]
2) Watari H., Shigyo M., Tanabe N., Tohda M., Cho K.H., Kyung P.S., Jung W.S., Shimada Y., Shibahara N., Kuboyama T., Tohda C.: Comparing the effects of kamikihito in Japan and kami-guibi-tang in Korea on memory enhancement: working towards the development of a global study. hytother Res. 29(3): 351-356, 2015. [Abstract]
3) Kee J.Y., Inujima A., Andoh T., Tanaka K., Li F., Kuraishi Y., Sakurai H., Shibahara N., Saiki I., Koizumi K.: Inhibitory effect of Moutan Cortex aqueous fraction on mast cell-mediated allergic inflammation. J Nat Med., 69(2): 209-217, 2015.[Abstract]
4) Wada A., Ito A., Iitsuka H., Tsuneyama K., Miyazono T., Murakami J., Shibahara N., Sakurai H., Saiki I., Nakayama T., Yoshie O., Koizumi K., Sugiyama T.: Role of chemokine CX3CL1 in progression of multiple myeloma via CX3CR1 in bone microenvironments. Oncol Rep., 33(6): 2935-2939, 2015. [Abstract]
5) Zhou Y., Yamada N., Tanaka T., Hori T., Yokoyama S., Hayakawa Y., Yano S., Fukuoka J., Koizumi K., Saiki I., Sakurai H.: Crucial roles of RSK in cell motility by catalysing serine phosphorylation of EphA2. Nat Commun., 6: 7679, doi: 10.1038/ncomms8679, 2015. [Abstract]
6) Takeno N., Inujima A., Shinohara K., Yamada M., Shibahara N., Sakurai H., Saiki I., Koizumi K.: Immune adjuvant effect of Juzentaihoto, a Japanese traditional herbal medicine, on tumor vaccine therapy in a mouse model. Int J Oncol., 47(6): 2115-2122, 2015. [Abstract]
7) Inujima A., Yamada M., Takeno N., Hoshina A., Oe M., Shinohara K., Shibahara N., Sakurai H., Saiki I., Koizumi K.: Herbal plant-derived compound, 1,2,3,4,6-penta-O-galloyl-β-D-glucose, increases cross-presentation by dendritic cells. Traditional & Kampo Med., 2(2): 43-49, 2015. [Abstract]


2014

1) Andoh T, Kitamura R, Fushimi H, Komatsu K, Shibahara N, Kuraishi Y: Effects of goshajinkigan, hachimijiogan, and rokumigan on mechanical allodynia induced by Paclitaxel in mice. J Tradit Complement Med., 4: 293-297, 2014. [Abstract]
2) Watari H, Shigyo M, Tanabe N, Tohda M, Cho KH, Kyung PS, Jung WS, Shimada Y, Shibahara N, Kuboyama T, Tohda C: Comparing the Effects of Kamikihito in Japan and Kami-Guibi-Tang in Korea on Memory Enhancement: Working Towards the Development of a Global Study. Phytother Res., doi: 10.1002/ptr.5250, 2014. [Abstract]
3) Kee JY, Ito A., Hojo S, Hashimoto I, Igarashi Y, Tsuneyama K, Tsukada K, Irimura T, Shibahara N, Takasaki I, Inujima A, Nakayama T, Yoshie O, Sakurai H, Saiki I, Koizumi K: CXCL16 suppresses liver metastasis of colorectal cancer by promoting TNF-alpha-induced apoptosis by tumor-associated macrophages. BMC Cancer, 14: 949, 2014. [Abstract]
4) Kee JY, Inujima A., Andoh T, Tanaka K, Li F, Kuraishi Y, Sakurai H, Shibahara N, Saiki I, Koizumi K: Inhibitory effect of Moutan Cortex aqueous fraction on mast cell-mediated allergic inflammation. J Nat Med., doi: 10.1007/s11418-014-0880-6, 2014. [Abstract]
5) 王子剛, 並木隆雄, 三谷和男, 植田圭吾, 中口俊哉, 貝沼茂三郎, 柴原直利, 三潴忠道, 小田口浩, 渡辺賢治, 藤井泰志, 喜多敏明, 小暮敏明, 小川恵子, 田原英一, 萩原圭祐, 矢久保修嗣, 南澤潔, 村松慎一, 和辻直, 花輪壽彦: 多施設での統一した舌診臨床診断記載の作成を目的とした日本の舌診文献調査. 日東医誌, 65: 224-230, 2014. [Abstract]


2013

1) Prangsaengtong O., Park J.Y., Inujima A., Igarashi Y., Shibahara N., and Koizumi K.: Enhancement of Lymphangiogenesis In Vitro via the Regulations of HIF-1α Expression and Nuclear Translocation by Deoxyshikonin. Evid. Based Complement. Alternat. Med., 2013; 2013: 148297. doi: 10.1155/2013/148297, 2013. [Abstract]
2) Kee J.Y., Ito A., Hojo S., Hashimoto I., Igarashi Y., Tsukada K., Irimura T., Shibahara N., Nakayama T., Yoshie O., Sakurai H., Saiki I., and Koizumi K.: Chemokine CXCL16 suppresses liver metastasis of colorectal cancer via augmentation of tumor-infiltrating natural killer T cells in a murine model. Oncol Rep., 29: 975-982, doi: 10.3892/or.2012.2185, 2013. [Abstract]
3) Shirouzu T., Watari K., Ono M., Koizumi K., Saiki I., Tanaka C., van Soest R.W., and Miyamoto T.: Structure, synthesis, and biological activity of a C-20 bisacetylenic alcohol from a marine sponge Callyspongia sp. J. Nat. Prod., 76(7): 1337-1342, doi: 10.1021/np400297p. 2013. [Abstract]
4) Sato K., Shin M.S., Sakimura A., Zhou Y., Tanaka T., Kawanishi M., Kawasaki Y., Yokoyama S., Koizumi K., Saiki I., and Sakurai H.: Inverse correlation between Thr-669 and constitutive tyrosine phosphorylation in the asymmetric epidermal growth factor receptor dimer conformation. Cancer Sci. 104(10): 1315-1322, doi: 10.1111/cas.12225, 2013. [Abstract]
5) Jeong D., Watari K., Shirouzu T., Ono M., Koizumi K., Saiki I., Kim Y.C., Tanaka C., Higuchi R., and Miyamoto T.: Studies on lymphangiogenesis inhibitors from Korean and Japanese crude drugs. Biol. Pharm. Bull., 36(1): 152-157, 2013. [Abstract]
6) Saiki I., Koizumi K., Goto H., Inujima A., Namiki T., Raimura M., Kogure T., Tatsumi T., Inoue H., Sakai S., Oka H., Fujimoto M., Hikiami H., Sakurai H., Shibahara N., Shimada Y., and Origasa H.: The long-term effects of a Kampo medicine, Juzentaihoto, on maintenance of antibody titer in elderly people after influenza vaccination. Evid. Based Complement. Alternat. Med., 2013:568074. doi: 10.1155/2013/568074, 2013. [Abstract]
7) Jo M., Nakagawa T., Kaneko M., Oka H., and Shibahara N.: Effect of Goreisan on urinary concentrating ability and expression of aquaporin-2 in 5/6 nephrectomized rats. J. Trad. Med., 30: 145-157, 2013.
8) Park J.Y., Koizumi K., Prangsaengtonga O., Inujima A., Igarashi Y., Jo M., and Shibahara N.: Shikonin inhibits lymphangiogenesis in vitro via the modulation of cell adhesion. J. Trad. Med., 30: 176-182, 2013.


2012

1) Zhao Q., Matsumoto K., Tsuneyama K., Tanaka K., Li F., Shibahara N., Miyata T., and Yokozawa T.: Diabetes-induced central cholinergic neuronal loss and cognitive deficit are attenuated by tacrine and a Chinese herbal prescription, kangen-karyu: elucidation in type 2 diabetes db/db mice. J. Pharmacol. Sci., 117: 230-242, 2011. [Abstract]
2) Park CH., Tanaka T., Cho EJ., Park JC., Shibahara N., and Yokozawa T.: Glycerol-induced renal damage improved by 7-O-galloyl-D-sedoheptulose treatment through attenuating oxidative stress. Biol. Pharm. Bull., 35: 34-41, 2012. [Abstract]
3) Koizumi K., Kato S., Sakurai H., Hashimoto I., Yasumoto K., and Saiki I.: Therapeutics target of CXCR4 and its downstream in peritoneal carcinomatosis of gastric cancer. Front. Biosci. (Schol. Ed.), 4:269-276, 2012.[Abstract]
4) Sanphanya K., Wattanapitayakul SK., Prangsaengtong O., Jo M., Koizumi K., Shibahara N., Priprem A., Fokin VV., and Vajragupta O.: Synthesis and evaluation of 1-(substituted)- 3-prop-2-ynylureas as antiangiogenic agents. Bioorg. Med. Chem. Lett., 22: 3001-3005, 2012. [Abstract]
5) Nagata Y., Goto H., Hikiami H., Nogami T., Fujimoto M., Shibahara N., and Shimada Y.: Effect of keishibukuryogan on endothelial function in patients with at least one component of the diagnostic criteria for metabolic syndrome: a controlled clinical trial with crossover design. Evid Based Complement. Alternat. Med., 2012: 359282, 2012. [Abstract]
6) Prangsaengtong O., Senda K., Doki Y., Park JY., Jo M., Sakurai H., Shibahara N., Saiki I., and Koizumi K.: Calpain 1 and -2 play opposite roles in cord formation of lymphatic endothelial cells via eNOS regulation. Hum. Cell, 25: 36-44, 2012. [Abstract]
7) Kudo Y., Iizuka S., Yoshida M., Nguyen PT., Siriwardena SB., Tsunematsu T., Ohbayashi M., Ando T., Hatakeyama D., Shibata T., Koizumi K., Maeda M., Ishimaru N., Ogawa I., and Takata T.: Periostin directly and indirectly promotes tumor lymphangiogenesis of head and neck cancer. PloS One, 7: e44488, 2012. [Abstract]
8) Kee JY., Ito A., Hojo S., Hashimoto I., Igarashi Y., Tsukada K., Irimura T., Shibahara N., Nakayama T., Yoshie O., Sakurai H., Saiki I., and Koizumi K.: Chemokine CXCL16 suppresses liver metastasis of colorectal cancer via augmentation of tumor-infiltrating natural killer T cells in a murine model. Oncol Rep., doi: 10.3892/or.2012.2185, 2012. [Abstract]


2011

1) Waiwut P., Shin MS., Inujima A., Zhou Y., Koizumi K., Saiki I., and Sakurai H.: Gomisin N enhances TNF-α-induced apoptosis via inhibition of the NF-κB and EGFR survival pathways. Mol. Cell Biochem., 350: 169-175, 2011. [Abstract]
2) Oka H., Goto H., Koizumi K., Nakamura S., Tsuneyama K., Zhou Y., Jo M., Fujimoto T., Sakurai H., Shibahara N., Saiki I., and Shimada Y.: Effect of Hachimijiogan against Renal Dysfunction and Involvement of Hypoxia-Inducible Factor-1α in the Remnant Kidney Model. Evid Based Complement. Alternat. Med., 2011: 348686, 2011. [Abstract]
3) Kimura M., Shibahara N., Hikiami H., Yoshida T., Jo M., Kaneko M., Nogami T., Fujimoto M., Goto H., and Shimada Y.: Traditional Japanese formula kigikenchuto accelerates healing of pressure-loading skin ulcer in rats. Evid Based Complement. Alternat. Med., 2011: 592791, 2011. [Abstract]
4) Yamada M., Hayashida M., Zhao Q., Shibahara N., Tanaka K., Miyata T., and Matsumoto K.: Ameliorative effects of yokukansan on learning and memory deficits in olfactory bulbectomized mice. J. Ethnopharmacol., 135: 737-746, 2011. [Abstract]
5) Refaat A., Zhou Y., Suzuki S., Takasaki I., Koizumi K., Yamaoka S., Tabuchi Y., Saiki I., and Sakurai H.: Distinct roles of transforming growth factor-beta-activated kinase 1 (TAK1)-c-Rel and interferon regulatory factor 4 (IRF4) pathways in human T cell lymphotropic virus 1-transformed T helper 17 cells producing interleukin-9. J. Biol. Chem., 286: 21092-21099, 2011. [Abstract]
6) Prangsaengtong O., Koizumi K., Senda K., Sakurai H., and Saiki I.: eNOS and Hsp90 interaction directly correlates with cord formation in human lymphatic endothelial cells. Lymphat. Res. Biol., 9: 53-59, 2011. [Abstract]
7) Waiwut P., Shin MS., Inujima A., Zhou Y., Koizumi K., Saiki I., and Sakurai H.: Gomisin N enhances TNF-α-induced apoptosis via inhibition of the NF-κB and EGFR survival pathways. Mol. Cell Biochem., 350: 169-175, 2011. [Abstract]
8) Park CH., Noh JS., Kim JH., Tanaka T., Zhao Q., Matsumoto K., Shibahara N., and Yokozawa T.: Evaluation of Morroniside, Iridoid Glycoside from Corni Fructus, on Diabetes-Induced Alterations such as Oxidative Stress, Inflammation, and Apoptosis in the Liver of Type 2 Diabetic db/db Mice. Biol. Pharm. Bull., 34: 1559-1565, 2011. [Abstract]
9) Arita M., Yoshimoto M., Suwa K., Hirai A., Kanaya S., Shibahara N., and Tanaka K.: Database for Crude Drugs and Kampo Medicine. Genome Informatics, 25: 1-11, 2011. [Abstract]
10) Park CH., Tanaka T., Kim JH., Cho EJ., Park JC., Shibahara N., and Yokozawa T.: Hepato-protective effects of loganin, iridoid glycoside from Corni Fructus, against hyperglycemia-activated signaling pathway in liver of type 2 diabetic db/db mice. Toxicology, 290: 14-21, 2011. [Abstract]
11) Zhao Q., Yokozawa T., Tsuneyama K., Tanaka K., Miyata T., Shibahara N., and Matsumoto K.: Chotosan(Diaoteng San)-induced improvement of cognitive deficits in senescence-accelerated mouse (SAMP8) involves the amelioration of angiogenic/neurotrophic factors and neuroplasticity systems in the brain. Chin. Med., 6:33, 2011. [Abstract]
12) Park CH., Yamabe N., Okamoto T., Toriizuka K., and Yokozawa T.: Chinese prescription kangen-karyu ameliorates the development of diabetic hepatic damages via regulating oxidative stress and inflammation in the liver of db/db mice. Biol. Pharm. Bull., 34: 383-388, 2011.
13) Noh JS., Park CH., Kim HY., Zhao Q., Yamabe N., Matsumoto K., and Yokozawa T.: Chinese prescription Kangen-karyu prevents dyslipidaemia and oxidative stress in mouse model of type 2 diabetes. J. Pharm. Pharmacol., 63: 111-119, 2011. [Abstract]
14) Oka H., Goto H., Koizumi K., Nogami T., Watari H., Nakamura S., Zhou Y., Sakurai H., Shibahara N., Saiki I., and Shimada Y.: Cinnamaldehide and paeonol increase HIF-1α activity in proximal tubular epithelial cells under hypoxia. J. Trad. Med., 28: 149-157, 2011. [Abstract]


2010

1) Park CH., Noh JS., Yamabe N., Okamoto T., Kang KS., Zhao Q., Matsumoto K., Shibahara N., and Yokozawa T.: Renoprotective effect of Kangen-karyu on the development of diabetic nephropathy in type 2 diabetic db/db mice. J. Trad. Med., 27: 192-203, 2010. [Abstract]
2) Prangsaengtong O., Koizumi K., Senda K., Urano T., Nagata A., Sakurai H., Tohda C., and Saiki I.: Methanol extract of Polygonati Rhizoma enhances the tube formation of rat lymphatic endothelial cell. J. Trad. Med., 27: 59-65, 2010.
3) Shimada K., Kawase M., Shibahara N., Nakamura Y., Saito T., and Takahashi K.: The relation between clinical effects of Tokishakuyakusan and the identity of Paeonia lactiflora materials. J. Ethnopharmacol., 132: 438-442, 2010. [Abstract]
4) Suzuki S., Zhou Y., Refaat A., Takasaki I., Koizumi K., Yamaoka S., Tabuchi Y., Saiki I., and Sakurai H.: Human T cell lymphotropic virus 1 manipulates interferon regulatory signals by controlling the TAK1-IRF3 and IRF4 pathways. Biol. Chem., 285: 4441-4446, 2010. [Abstract]
5) Suzuki S., Zhou Y., Refaat A., Takasaki I., Koizumi K., Yamaoka S., Tabuchi Y., Saiki I., and Sakurai H.: HTLV-1 manipulates interferon regulatory signals by controlling TAK1-IRF3 and IRF4. J. Biol. Chem., 285: 4441-4446, 2010. [Abstract]
6) Lirdprapamongkol K., Sakurai H., Suzuki S., Koizumi K., Prangsaengtong O., Viriyaroj A., Ruchirawat S., Svasti J., and Saiki I.: Vanillin enhances TRAIL-induced apoptosis in cancer cells through inhibition of NF-κB activatin. In Vivo, 24: 501-506, 2010. [Abstract]
7) Kato S., Koizumi K., Yamada M., Inujima A., Takeno N., Nakanishi T., Sakurai H., Nakagawa S., and Saiki, I.: A phagocytotic inducer from herbal constituent, pentagalloylglucose (PGG) enhances lipoplex-mediated gene transfection in dendritic cells. Biol. Pharm. Bull., 33: 1878-1885, 2010. [Abstract]
8) Yamabe N., Kim HY., Kang KS., Zhao Q., Matsumoto K., Yokozawa T.: Effect of Chinese prescription Kangen-karyu on lipid metabolism in type 2 diabetic db/db mice. J. Ethnopharmacol., 129: 299-305, 2010. [Abstract]
9) Park CH., Noh JS., Yamabe N., Kang KS., Tanaka T., Yokozawa T.: Beneficial effect of 7-O-galloyl-D-sedoheptulose on oxidative stress and hepatic and renal changes in type 2 diabetic db/db mice. Eur. J. Pharmacol., 640: 233-242, 2010. [Abstract]
10) Kang KS., Yamabe N., Kim HY., Park JH., Yokozawa T.: Effects of heat-processed ginseng and its active component ginsenoside 20(S)-Rg3 on the progression of renal damage and dysfunction in type 2 diabetic Otsuka Long-Evans Tokushima Fatty rats. Biol. Pharm. Bull., 33: 1077-1081. [Abstract]
11) Zhao Q., Yokozawa T., Yamabe N., Tsuneyama K., Li X., Matsumoto K.: Kangen-karyu improves memory deficit caused by aging through normalization of neuro-plasticity-related signaling system and VEGF system in the brain. J. Ethnopharmacol., 131: 377-385, 2010. [Abstract]


2009

1) Nakagawa T., Tashiro I., Fujimoto M., Jo M., Sakai S., Oka H., Goto H., Shimada Y. and Shibahara N.: Keishibukuryogan Reduces Renal Injury in the Early Stage of Renal Failure in the Remnant Kidney Model. Evid Based Complement Alternat Med., 2009 [in print].[Abstract]