病態生化学分野
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研究業績

≪ 前年 2006年 翌年 ≫

Books and Reviews

1) Tani T., Shimada Y., and Saiki I.:
A new formulation containing eleven crude drugsdevised by the cooperative research project in Toyama.
J. Trad. Med., 23: 5-15, 2006.
2) Awale S., Linn T.Z., Than M.M. Swe T., Saiki I. and Kadota S.:
The healing art of traditional medicines in Myanmar.
J. Trad. Med., 23: 47-68, 2006.
3) 済木育夫: 特集「癌の漢方療法−新しい展開」、1. 漢方薬による癌転移阻害のメ カニズム. Biotherapy, 20: 23-32, 2006.
4) 済木育夫: Serial東洋医学と生命科学の融合を目指して、漢方医学における 「証」の科学的解析. Biophilia, 6:54-58, 2006.

Original Papers

1) Yasumoto K., Koizumi K., Kawashima A., Saitoh Y., Arita Y., Shinohara K. Minami T., Nakayama T., Sakurai H., Takahashi Y., Yoshie O., and Saiki I.:
Role of the CXCL12/CXCR4 axis in peritoneal carcinomatosis of gastric cancer.

Cancer Res., 66: 2181-2187, 2006. [Abstract]
2) Matsuo M., Sakurai H., Ueno Y., Ohtani O., and Saiki I.:
Activation of ERK and PI3K/Akt pathways by fibronectin requires integrin αv-mediated ADAM activity in hepatocellular carcinoma: a novel functional target for gefitinib.
Cancer Sci., 97: 155-162, 2006. [Abstract]
3) Choo M.K., Sakurai H., Koizumi K., and Saiki I.:
TAK1-mediated stress signaling pathways are essential for TNF-α-promoted pulmonary metastasis of murine colon cancer cells.
Int. J. Cancer, 118: 2758-2764, 2006. [Abstract]
4) Lee S.J., Sakurai H., Koizumi K., Song G.Y., Bae Y.S., Kim H.M., Kang K.S., Surh Y.J., Saiki I., and Kim S.H.:
MAPK regulation and caspase activation are required in DMNQ S-52 induced apoptosis in Lewis lung carcinoma cells.
Cancer Lett., 233: 57-67, 2006. [Abstract]
5) Fukasawa K., Fujii H., Saitoh Y., Koizumi K., Aozuka Y., Sekine K., Yamada M., Saiki I., and Nishikawa K.:
Aminopeptidase N (APN/CD13) is selectively expressed in vascular endothelial cells and plays multiple roles in angiogenesis.

Cancer Lett., 243: 135-143, 2006. [Abstract]
6) Saitoh Y., Koizumi K., Minami T., Sekine K., Sakurai H., and Saiki I.:
A derivative of aminopeptidase inhibitor (BE15) has a dual inhibitory effect of invasion and motility on tumor and endothelial cells.

Biol. Pharm. Bull., 29: 709-712, 2006. [Abstract]
7) Fuke Y., Shinoda S., Nagata I., Sawaki S., Nomura T., Ryoyama K., Koizumi K., and Saiki I.:
Preventive effect of oral administrationof 6-(methylsulfinyl)hexyl isothiocyanate from wasabi (Wasabia japonica Matsum) against pulmonary metastasis of B16-BL6 mouse melanoma cells.

Cancer Detect. Prev., 30: 174-179, 2006. [Abstract]
8) Nakamura E.S., Koizumi K., Kobayashi M., Saitoh Y., Arita Y., Nakayama T., Sakurai H., Yoshie O., and Saiki I.:
RANKL-induced CCL22/macrophage-derived chemokine produced from osteoclasts potentially promotes the bone metastasis of lung cancer expressing its receptor CCR4.

Clin. Exp. Metastasis, 23: 9-18, 2006. [Abstract]
9) Ogawa H., Gomi T., Nishizawa M., Hayakawa Y., Endo S., Hayashi K., Ochiai H., Takusagawa F., Pitot H.C., Mori H., Sakurai H., Koizumi K., Saiki I., Oda H., Fujishita T., Miwa T., Maruyama M., and Kobayashi M.:
Enzymatic and biochemical properties of a novel human serine dehydratase isoform.
Biochim Biophys Acta
, 1764: 961-971, 2006. [Abstract]
10) Matsuo M., Koizumi K., Yamada S., Tomi M., Takahashi R., Ueda M., Terasaki T., Obinata M., Hosoya K., Ohtani O., and Saiki I.:
Establishment and characterization of conditionally immortalized endothelial cell lines from the thoracic duct and inferior vena cava of tsA58/EGFP double-transgenic rats.
Cell Tissue Res.
, 326: 749-758, 2006. [Abstract]
11) Suzuki S., Singhirunnusorn P., Nakano H., Doi T., Saiki I., and Sakurai H.:
Identification of TNF-α-responsive NF-κB p65-binding element in the distal promoter of the mouse serine protease inhibitor SerpinE2.
FEBS Lett.
, 580: 3257-3262, 2006. [Abstract]
12) Sakurai H., Choo M.K., Chino A., Tega E., Iwasaki T., Kobayashi H., Saiki I.:
Antimetastatic and immunostimulatory properties of fermented brown rice.
J. Trad. Med.
, 23: 112-116, 2006.
13) Thiefes A., Wolf A., Grassl G.A., Doerrie A., Matsumoto K., Autenrieth I., Bohn E., Sakurai H., Niedenthal R., Resch K., and Kracht M.:
The Yersinia enterocolitica effector YopP inhibits host cell signalling by inactivating the protein kinase TAK1 in the IL-1 signalling pathway.
EMBO Rep.
, 7: 838-844, 2006. [Abstract]
14) Akashi T., Koizumi K., Nagakawa O., Fuse H., and Saiki I.:
Androgen receptor negatively influences the expression of chemokine receptors (CXCR4, CCR1) and ligand-mediated migration in prostate cancer DU-145.
Oncol. Rep.
, 16: 831-836, 2006. [Abstract]
15) Mori A., Sakurai H., Choo M.K., Obi R., Koizumi K., Yoshida C., Shimada Y., and Saiki I.:
Severe pulmonary metastasis in diabetic and obese mice.
Int. J. Cancer, 119: 2760-2767, 2006. [Abstract]
16) Yamamoto M., Okamoto Y., Takeda T., Sato S., Sanjo H., Uematsu S., Saitoh T., Yamamoto N., Sakurai H., Ishii K.J., Yamaoka S., Kawai T., Matsuura Y., Takeuchi O., and Akira S.:
Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling.
Nat. Immunol., 7: 962-970, 2006. [Abstract]
17) Choo M.K., Kawasaki N., Singhirunnusorn P., Koizumi K., Sato S., Akira S., Saiki I., and Sakurai H.:
Blockade of transforming growth factor-β-activated kinase 1 activity enhances TRAIL-induced apoptosis through activation of a caspase cascade.
Mol. Cancer Ther., 5: 2970-2976, 2006. [Abstract]
18) Yamamoto M., Sato S., Saitoh T., Sakurai H., Uematsu S., Kawai T., Ishii K.J., Takeuchi O., and Akira S.:
Cutting Edge: Pivotal function of Ubc13 in thymocyte TCR signaling.
J. Immunol., 177: 7520-7524, 2006. [Abstract]
19) Miyanaga S., Obata T., Onaka H., Fujita T., Saito N., Sakurai H., Saiki I., Furumai T., and Igarashi Y.:
Absolute configuration and antitumor activity of myxochelin A produced by Nonomuraea pusilla TP-A0861
J. Antibiot., 59: 698-703, 2006. [Abstract]
20) Kushida S., Ohmae H., Kamma H., Totsuka R., Matsumura M., Takeuchi A., Saiki I. Yanagawa T., Onizawa K., Ishii T., and Ohno T.:
Artificial cytokine storm combined with hyperthermia induces significant anti-tumor effect in mice inoculated with Lewis lung carcinoma and B16 melanoma cells.
Int. J. Hyperthermia, 22: 699-712, 2006.

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富山大学和漢医薬学総合研究所 病態生化学分野
〒 930-0194 富山市杉谷2630
TEL 076-434-7620

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