病態生化学分野
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研究業績

≪ 前年 2015年 翌年 ≫

著書、総説

1) 安東嗣修、済木育夫:特集I 「末梢神経障害を緩和するために」、解説「さまざまな神経障害性疼痛と漢方薬」、パクリタキセルの末梢神経障害および抗腫瘍作用に対する牛車腎気丸の影響、漢方医学、39(1): 12-15, 2015.
2) 後藤博三、小泉桂一、済木育夫:急性感染症:予防 高齢者のインフルエンザワクチンに 対する漢方アジュバント効果に関する臨床研究、漢方と最新治療、24(2): 123-129, 2015

原著論文

1) Kee J-Y., Inujima A., Andoh T., Tanaka K., Li F., Kuraishi Y., Sakurai H., Shibahara N., Saiki I., Koizumi K.:
Inhibitory effect of Moutan cortex aqueous fraction on mast cell-mediated allergic inflammation.
J. Nat. Med., 69(2), 209-217, 2015.[Abstract]
2) Ajdzanovic V., Medigovic I., Zivanovic J., Mojic M., Milosevic V.:
Membrane steroid receptor-mediated action of soy isoflavones:Tip of the iceberg.

J. Membr. Biol.
, 248(1), 1-6, 2015.[Abstract]
3) Muhammad J.S., Zaidi S.F., Shaharyar S., Refaat A., Usmanghani K., Saiki I., Sugiyama T.:
Anti-inflammatory effect of cinnamaldehyde in Helicobacter pylori induced gastric inflammation.
Biol. Pharm. Bull., 38(1), 109-115, 2015.[Abstract]
4) Xue R., Han N., Xia M., Ye C., Hao Z., Wang L., Wang Y., Yang J., Saiki I., Yin J.:
TXA9, a cardiac glycoside from Streptocaulon juventas, exerts a potent anti-tumor activity against human non-small cell lung cancer cells in vitro and in vivo.
Steroids., 94, 51-59, 2015.[Abstract]
5) Lou C., Yokoyama S., Saiki I., Hayakawa Y.:
Selective anti-cancer activity of Hirsutine against HER2 positive breast cancer cells by inducing DNA damage.
Oncol. Rep., 33(4), 2072-2076, 2015.[Abstract]
6) Toge M., Yokoyama S., Kato S., Sakurai H., Senda K., Doki Y., Hayakawa Y., Yoshimura N., Saiki I.:
Critical contribution of MCL-1 in EMT-associated chemo-resistance in A549 non-small-cell lung cancer.
Int J. Oncol., 46(4), 1844-1848, 2015.[Abstract]
7) Gao F., Yokoyama S., Fujimoto M., Tsuneyama K., Saiki I., Shimada Y., Hayakawa Y.:
Effect of keishibukuryogan on genetic and dietary obesity models.
Evid. Based Complement Alternat. Med., volume 2015 (2015), Article ID 801291.[Abstract]
8) Refaat A., Aminullah, Zhou Y., Kawanishi M., Tomaru R., Abdelhamed S., Shin M-S, Koizumi K., Yokoyama Y., Saiki I., Sakurai H.:
Role of tyrosine kinase-independent phosphorylation of EGFR with activating mutation in cisplatin-treated lung cancer cells.
Biochem. Biophys. Res. Commun., 458, 856-861, 2015.[Abstract]
9) Zaidi S.F., Refaat A., Shin M-S., Zhou Y., Muhammad J.S., Saiki I., Sakurai H., Sugiyama T.:
Helicobacter pylori induces serine/threonine phosphorylation of EGFR via p38/ERK activation in gastric epithelial cells in HB-EGF-independent manner.
Helicobacter., doi: 10.1111/hel.12215., 2015.[Abstract]
10) Inujima A., Yamada M., Takeno N., Hoshina A., Oe M., Shinohara M., Shibahara N., Sakurai H., Saiki I., Koizumi K.:
An herbal plant derived compound, 1,2,3,4,6-penta-O-galloyl-β-D- glucose (PGG), increases cross-presentation of antigens to MHC class I molecules in dendritic cells.
Trad. Kampo Med., 23 FEB 2015 doi:10.1002/tkm2.1017.[Abstract]
11) Wada A., Ito A., itsuka H., Tsuneyama K., Miyazono T., Murakami J., Shibahara N., Sakurai H., Saiki I., Nakayama T., Yoshie O., Koizumi K., Sugiyama T.:
Role of chemokine CX3CL1 in progression of multiple myeloma via CX3CR1 in bone microenvironments.

Oncol. Rep.
, 33(6),2935-2939, 2015.[Abstract]
12) Refaat A., Abdelhamed S., Saiki I., Sakurai H.:
Inhibition of p38 MAPK potentiates the apoptotic effect of berberine/TRAIL combination.
Oncol. Lett., 10,1907-1911,2015.[Abstract]
13) Gao F., Yokoyama S., Fujimoto M., Tsuneyama K., Saiki I., Shimada Y., Hayakawa Y.:
Comparative of two Kampo medicines in a diet-induced mouse obesity model.
Trad. Kampo Med., 13 MAY 2015 doi:10.1002/tkm2.1021.[Abstract]
14) Takahashi K., Nagai N., Tsuneyama K., Saiki I., Irimura T., Hayakawa Y.:
Mammary tissue microenvironment determines T cell-dependent breast cancer-associated inflammation.
Cancer Sci., 106(7),867-874,2015.[Abstract]
15) Eshima S., Yokoyama S., Abe T., Hayakawa Y., Saiki I.:
Multi-pathway cellular analysis on crude natural drugs/herbs from Japanese Kampo formulations
PLoS ONE, 2015 Jun 2;10(6):e0128872.doi:10.1371/journal.pone.0128872.[Abstract]
16) Mudjupa C., Abdelhamed S., Refaat A., Yokoyama S., Saiki I., Vajragupta O.:
Lead compound bearing caffeic scaffold induces EGFR suppression in solid tumor cancer cells.
J. Applied Biomed., doi:10.1016/j.jab.2015.05.001.[Abstract]
17) Zhou Y., Yamada N., Tanaka T., Hori T., Yokoyama S., Hayakawa Y., Yano S., Fukuoka J., Koizumi K., Saiki I., Sakurai H.:
Crucial roles of RSK in cell motility by catalyzing serine phosphorylation of EphA2.
Nature commun., 2015 Jul 9;6:7679. doi: 10.1038/ncomms8679.[Abstract]
18) Lou C., Yokoyama S., Abdelhamed S., Saiki I., Hayakawa Y.:
Targeting ATM pathway for effective therapy against hirsutine-resistant breast cancer cells.
Oncol. Lett., in press, 2015.[Abstract]
19) Managit C., Sakurai H., Saiki I.:
The ethanolic extract of Thevetia Peruviana flowers enhances TNF-α and TRAIL-induced apoptosis of human cervical cancer cells via intrinsic and extrinsic pathways.
Oncol. Letts., in press, 2015.[Abstract]
20) .Takeno N., Inujima A., Shinohara K., Yamada M., Shibahara N., Sakurai H., Saiki I., Koizumi K.:
Immune adjuvant effect of Juzentaihoto, a Japanese traditional herbal medicine, on tumor vaccine therapy in mouse model.
Int J. Oncol.,47(6), 2115-2122, 2015 .[Abstract]

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