富山大学和漢医薬学総合研究所 資源開発研究部門 生薬資源科学分野 English
  分野概要 スタッフ メンバー 研究業績 薬用資源調査 アルバム リンク  
                             

スタッフ

朱 助教 朱 姝 博士 (薬学) Ph. D.
富山大学 和漢医薬学総合研究所
資源開発研究部門 生薬資源科学分野 助教
〒930-0194 富山市杉谷2630

研究内容

  1. 薬用植物の分子系統学的解析
  2. 遺伝子多型に基づく生薬同定法の開発
  3. 生薬の品質評価

原著論文

36) Zhu S., Bai Y. J., Oya M., Tanaka K., Komatsu K., Maruyama T., Goda Y., Kawasaki T., Fujita M., Shibata T.: Genetic and chemical diversity of Eleutherococcus senticosus and molecular identification of Siberian ginseng by PCR-RFLP analysis based on chloroplast trnK intron sequence. Food Chemistry, 129: 1844-1850, 2011.
35) Kitani Y.,Zhu S., Batkhuu J., Sanchir C., Komatsu K.: Genetic diversity of Ephedra plants in Mongolia inferred from internal transcribed spacer sequence of nuclear ribosomal DNA. Biol. Pharm. Bull., 34: 717-726, 2011.
34) Rinthong P. O.,Zhu S., Komatsu K., Chanama S., De-Eknamkul W.: Genetic variation of Croton stellatopilosus Ohba based on non-coding DNA sequences of ITS, trnK and trnL-F regions. J. Nat. Med., 65: 641-645, 2011.
33) Bai Y. J., Tohda C., Zhu S., Hattori M., Komatsu K.: Active components from Siberian ginseng (Eleutherococcus senticosus) for protection of amyloid β(25-35)-induced neuritic atrophy in cultured rat cortical neurons. J. Nat. Med., 65: 417-423, 2011.
32) Hung T. M., Cuong T. D., Dang N. H., Zhu S., Long P. Q., Komatsu K., Min B. S. Flavonoid glycosides from Chromolaena odorata leaves and their in vitro cytotoxic activity. Chem. Pharm. Bull., 59:129-131, 2011.
31) Guo Z., Zou K., Dan F., Wang J., Zhu S., Komatsu K. Panajaponin, a new glycosphingolipid from Panax japonicus. Nat. Prod. Res., 24: 86-91, 2010.
30) Watthanachaiyingcharoen R., Komatsu K., Zhu S., Vajragupta O., Leelamanit W. Authentication of Coscinium fenestratum among the other menispermaceae plants prescribed in Thai folk medicines. Biol. Pharm. Bull., 33: 91-4. 2010.
29) Maruyama T., Kondo K., Yotsuyanagi Y., Yamamoto Y., Kawasaki T., Shiba M., Terasaki K., Yamane M., Zhu S., Skata K., Fujita M., Akiyama H., Nishimura N., Komatsu K., Mizukami H., Goda Y. The inter-laboratory validation study for the purity test of Atractylodes Rhizome targeted for Atractylodes Lancea Rhizome besed on PCR-RFLP. The Japanese Journal of Pharmacognosy,64: 96-101, 2010.
28) Zhu S., Sugiyama R., Batkhuu J., Sanchir C., Zou K., Komatsu K. Survey of Glycyrrhizae Radix Resource in Mongolia: Chemical assessment on the underground part of Glycyrrhiza uralensis and comparison with Chinese Glycyrrhizea Radix. J. Nat. Med., 63:137-146, 2009.
27) Kitani Y., Zhu S., Omote T., Tanaka K., Batkhuu J., Sanchir C., Fushimi H., Mikage M., Komatsu K. Molecular analysis and chemical evaluation of Ephedra plants in Mongolia. Biol. Pharm. Bull., 7: 1235-1243, 2009.
26) Fan L. L.#, Zhu S.#(Co-1st author), Chen H. B., Yang D. H., Cai S. Q., Komatsu K. Molecular analysis of Stemona plants in China based on sequences of four chloroplast DNA regions. Biol. Pharm. Bull., 8: in press, 2009.
25) Fan L. L.#, Zhu S.#(Co-1st author), Chen H. B., Yang D. H., Cai S. Q., Komatsu K. Identification of the Botanical Source of Stemonae Radix Based on PCR with Specific Primers and PCR-RFLP. Biol. Pharm. Bull., 9: in press, 2009.
24) Zhu S., Fushimi H., Komatsu K.: Development of a DNA microarray for authentication of ginseng drugs based on 18S rRNA gene sequence. J. Agric. Food. Chem., 56: 3953-3959, 2008.
23) Liu H. Y., Zhu S., Komatsu K., Cai S. Q., Li Y. H., Yu C., Jiang Y., Sa Y.: Study on aqueous chemical constituents from the flower buds of Eugenia caryophylla. Zhong Yao Cai. 31: 998-1000, 2008.
22) Tohda C., Ichimura M., Bai Y., Tanaka K., Zhu S., Komatsu K.: Inhibitory effects of Eleutherococcus senticosus extracts on amyloid beta(25-35)-induced neuritic atrophy and synaptic loss. J. Pharmacol. Sci., 107: 329-339, 2008.
21) Zhu S., Fushimi H., Han G., Tsuchida T., Uno T., Takano A., and Komatsu K.: Molecular Identification of “Chuanxiong” by Nucleotide Sequence and Multiplex Single Base Extension Analysis on Chloroplast trnK Gene. Biol. Pharm. Bull., 30: 527-531, 2007.
20) Zou K., Komatsu K., and Zhu S.: A Novel Compound from Hedysarum polybotrys. J. Asian Nat. Prod. Res., 9: 481-485, 2007.
19) Tanaka K., Kubota M., Zhu S., Sankawa U., and Komatsu K.: Analysis of Ginsenosides in Ginseng Drugs Using Liquid Chromatography-Fourier Transform Ion Cyclotron Resonance Mass Spectrometry. Nat. Prod. Comm., 2: 625-632, 2007.
18) Sukrong S., Zhu S., Ruangrungsi N., Phadungcharoen T., Palanuvej C., and Komatsu K.: Molecular Analysis of the Genus Mitragyna Existing in Thailand Based on rDNA ITS Sequences and Its Application to Identify A Narcotic Species: Mitragyna speciosa. Biol. Pharm. Bull., 30: 1284-1288, 2007.
17) Komatsu K., Tohda C., and Zhu S.: Ginseng drugs - Molecular and Chemical Characteristics and Possibility as Antidementia Drugs. Current Topics in Nutraceutical Res., 3: 47-64, 2005.
16) Komatsu K., Zhu S., and Sasaki Y.: Systematic Pharmacognostical Study on Panax Drugs and Curcuma Drugs - Phylogenetic Analysis, Molecular Authentication and Quality Evaluation -. J. Trad. Med., 21: 251-270, 2004.
15) Zhu S., Zou K., Fushimi H., Cai S. Q., and Komatsu K.: Comparative Study on Triterpene Saponins of Ginseng Drugs. Planta Med., 70: 666-677, 2004.
14) Zhu S., Zou K., Cai S. Q., Meselhy M. R., and Komatsu K.: Simultaneous Determination of Triterpene Saponins in Ginseng Drugs by High Performance Liquid Chromatography. Chem. Pharm. Bull., 52: 995-998, 2004.
13) Zhu S., Fushimi H., Cai S. Q., and Komatsu K.: Species Identification from Ginseng Drugs by Multiplex Amplification Refractory Mutation System (MARMS). Planta Med., 70: 189-192, 2004.
12) Zhu S., Fushimi H., Cai S. Q., Chen H., and Komatsu K.: A New Variety of the Genus Panax from Southern Yunnan, China and Its Nucleotide Sequences of 18S Ribosomal RNA Gene and matK Gene. J. Jpn. Bot., 78: 86-94, 2003.
11) Zhu S., Fushimi H., Cai S. Q., and Komatsu K.: Phylogenetic Relationship in Genus Panax: Inferred from Chloroplast trnK Gene and Nuclear 18S rRNA Gene Sequences. Planta Med., 69: 647-653, 2003.
10) Tran Q. L., Than M. M., Tezuka Y., Banskota A. H., Kouda K., Watanabe H., Zhu S., Komatsu K., Thet M. M., Swe T., Maruyama Y., and Kadota S.: Wild Ginseng Grows in Myanmar. Chem. Pharm. Bull., 51: 679-682, 2003.
9) Zou K., Zhu S., Tohda C., Cai S. Q., and Komatsu K.:Dammarane-type triterpene saponins from Panax japonicus. J. Nat. Prod., 65: 346-351, 2002. *The material plant used in this study has been named as Panax vietnamensis var. fuscidiscus komatsu K, Zhu S. et Cai S.Q. based on genetic and chemical evidences. (referred to paper No. 13 above)
8) Zou K., Zhu S., Meselhy M. R., Tohda C., Cai S. Q., and Komatsu K.:Dammarane-type saponins from Panax japonicus and their neurite outgrowth activity in SK-N-SH cells. J. Nat. Prod., 65: 1288-1292, 2002.*The material plant used in this study has been named as Panax vietnamensis var. fuscidiscus komatsu K, Zhu S. et Cai S.Q. based on genetic and chemical evidences. (referred to paper No. 13 above)
7) Zou K., Zhu S., and Komatsu K. Analysis of Saponins of Panax Stipuleanatus by Using HPLC and APIMS/MS Techniques. J. China Three Gorges Univ. (Natural Sciences) 24(4): 355-357, (2002).
6) Komatsu K., Zhu S., Fushimi H., Qui T.K., Cai S.Q., and Kadota S.: Phylogenetic Analysis Based on 18S rRNA Gene and matK Gene Sequences of Panax vietnamensis and Five Related Species. Planta Med., 67: 461-465, 2001.
5) Ma C.M., Nakamura N., Hattori M., Zhu S., and Komatsu K.: Guaiane Dimers and Germacranolide from Artemisia caruifolia. J. Nat. Prod., 63: 1626-1627, 2000.
4) Cai S. Q., Zhu S. and Wang X., Macroscopic study on Chinese drug, Herba Asari. J. of China Pharmaceutical Univ. 1997. 28: 46-49.
3) Cai S. Q., Wang X., Zhu S., Li J. S., Lou Z. C., Namba T. and Komatsu K. Botanical origin of commercial samples of traditional Chinese drug xixin (Herba Aasari). China J. Chinese material Medica. 1996. 21: 712-717, 760.
2) Cai S. Q., Wang X., Zhu S. and Lou Z. C. Herbological study of Chinese traditional drug Xixin (Herba Asari). J. of Beijing Medical Univ. 1997, 29: 233-235.
1) Cai S. Q., Chen S. Z., Xie L. H. and Zhu S. The influence of plant age and collecting period on the volatile oil of Asarum heterotropoidies var. mandshuricum roots. J. Beijing Medical Univ. 1997, 29: 336-338, 371.
© Shoyaku Shigen Kagaku Bun'ya

富山大学和漢医薬学総合研究所 資源開発研究部門 生薬資源科学分野
〒930-0194 富山県富山市杉谷 2630
TEL: 076-434-7601 / FAX: 076-434-5064
和漢医薬学総合研究所
富山大学