松本 欣三 (薬学博士,薬剤師)

富山大学和漢医薬学総合研究所
複合薬物薬理学分野 教授
〒930-0194 富山市杉谷2630
電話    076-434-7610
ファックス 076-434-5056


研究テーマ
1)和漢薬・伝統薬の薬効を基盤とした認知症の予防・治療薬および治療法の開発
2)和漢薬・天然薬物の抗認知症効果を担う生薬由来責任分子,生体由来責任分子の同定と作用機序の解明
3)ストレスで誘導されるエピジェネティックな神経精神障害の発症機構の解明と和漢薬による予防治療
4)中枢神経細胞障害の救助因子,救助機構の解明とその応用


最近の研究成果

和漢薬・天然薬物の薬理

1.      Zhao Q., Yokozawa T., Tsuneyama T., Tanaka K., Miyata T., Shibahara N., Matsumoto K. Chotosan-induced improvement of cognitive deficits in senescence-accelerated mouse (SAMP8) involves normalization of angiogenic/neurotrophic factors and neuroplasticity systems in the brain Chinese Medicine 6:33, 2011

2.      Zhao Q., Matsumoto K., Tsuneyama K., Tanaka K., Li F., Shibahara N., Miyata T., Yokozawa T. Diabetes-induced central cholinergic neuronal loss and cognitive deficit are attenuated by tacrine and a Chinese herbal prescription, kangen-karyu: elucidation in type 2 diabetes db/db mice. J. Pharmacol. Sci. 117, 230-242, 2011

3.      Yamada M., Hayashida M., Zhao Q., Shibahara N., Tanaka K., Miyata T., Matsumoto K. Ameliorative effects of yokukansan on learning and memory deficits in olfactory bulbectomized mice. J Ethnopharmacol. 135(3):737-746, 2011

4.      Noh JS, Park CH, Kim HY, Zhao Q, Yamabe N, Matsumoto K, Yokozawa T. Chinese prescription Kangen-karyu prevents dyslipidaemia and oxidative stress in mouse model of type 2 diabetes. J Pharm Pharmacol. 63(1):111-119, 2011

5.      Zhao Q, Yokozawa T, Yamabe N, Tsuneyama K, Li X, Matsumoto K. Kangen-karyu improves memory deficit caused by aging through normalization of neuro-plasticity-related signaling system and VEGF system in the brain. J Ethnopharmacol. 131, 377-385, 2010

6.      Yamabe N, Kim HY, Kang KS, Zhao Q, Matsumoto K, Yokozawa T. Effect of Chinese prescription Kangen-karyu on lipid metabolism in type 2 diabetic db/db mice. J Ethnopharmacol. 129(3):299-305, 2010

7.      Cui H-S., Murakami Y., Hori H., Zhao Q., Obi R., Matsumoto K. Berberine exerts neuroprotective actions against in vitro ischemia-induced neuronal cell damage in organotypic hippocampal slice cultures: involvement of Bcl-2 phosphorylation suppression. Biol. Pharm. Bull. 32:79-85, 2009

 

ストレスおよび神経薬理

1.      Matsumoto, K., Ono K., Ouchi H., Tsushima R-H, Murakami Y.  Social isolation stress down-regulates cortical early growth response 1 (Egr-1) expression in mice. Neurosci Res 2012 in press

2.      Utsintong M., Rojsanga P., Ho K.-Y., Talley T.T., Olson A.J., Matsumoto K., Vajragupta O. Virtual Screening against Acetylcholine Binding Protein. Journal of Biomolecular Screening 2012 in press

3.      Hang P.N.T., Tohda M., Matsumoto K. Developmental changes in expression and self-editing of adenosine deaminase type 2 pre-mRNA and mRNA in rat brain and cultured cortical neurons. Neurosci Res 61 :398–403, 2008

4.      Tohda M, Hang PT, Kobayashi N, Matsumoto K. Serotonin 2C receptor (5-HT2CR) mRNA editing-induced down-regulation of 5-HT2CR function in Xenopus Oocytes: the significance of site C editing, J Pharmacol Sci. 113(4):362-367, 2010.

5.      Pham T.N. Hang, Tohda M., Tezuka Y., Matsumoto K. Influence of an adenosine deaminase inhibitor, erythro-9-(2-hydroxy-3-nonyl) adenine hydrochloride, on 5-HT2CR mRNA editing in primary cultured cortical cells, Biol Pharm Bull. 33(3):527-529, 2010

6.      Li S, Wang C, Wang M, Li W, Matsumoto K, Tang Y. Antidepressant like effects of piperine in chronic mild stress treated mice and its possible mechanisms, Life Sci. 80(15):1373-81, 2007

7.      Pinna G., Agis-Balboa RC, Zhubi A., Matsumoto K., Grayson D.R., Costa E., Guidotti A. Imidazenil and diazepam increase locomotor activity in mice exposed to protracted social isolation. Proc. Natl. Acad. Sci. USA 103(11): 4275-80, 2006

8.      Li S., Wang C., Wang M-W., Murakami Y, Matsumoto K. Impairment of the spatial learning and memory induced by learned helplessness and chronic mild stress, Pharmacol Biochem Behav. 83(2):186-193, 2006

9.      Li S., Murakami Y., Wang M., Maeda K, Matsumoto K. The effects of chronic valproate and diazepam in a mouse model of posttraumatic stress disorder, Pharmacol Biochem Behav. 85: 324–331, 2006




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