Reserchers

KOMATSU Katsuko Professor

KOMATSU Katsuko

AffiliationLaboratory of Pharmacognosy, Section of Pharmacognosy, Division of Medicinal Resources, Department of Research and Development

Research fieldsPharmacognosy, Medicinal Botany

Campus careerPh.D.(Pharmaceutical Sciences)

Biography Academic Research Staff

Education

1979 B.S., Faculty of Pharmaceutical Sciences, Toyama University, Japan
1986 M.S., Graduate School of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Japan
1986 Ph.D., Toyama Medical and Pharmaceutical University, Japan

Job career

1990 Assistant Professor, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Japan
1996 Associate Professor, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Japan
2004 Professor, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Japan
2005 Professor, Institute of Natural Medicine, University of Toyama, Japan

Research theme

Department

Division

Section

Project

Outline of the research

Natural resources of herbal drugs are gradually decreasing in many countries due to environmental degradation resulted from global warming and human made catastrophes. Diversity is the key to sustain environment including natural resources. For herbal drugs and the formulations, however, the safety and efficacy must be secured. Therefore, it is necessary to standardize the herbal drugs through limiting the acceptable range of diversity in quality. Aiming for standardizing herbal drugs and developing the methods for sustainable use of medicinal resources, I engage in the following subjects.

1. Field investigation on herbal drug resources around Asian countries and analysis on diversity of the medicinal plants from genetic, chemical and pharmacological aspects.
2. Quality evaluation of medicinal plants aiming for selecting proper species for cultivation and expanding domestic cultivation.
3. Standardization of herbal drugs based on genetic polymorphisms and chemical constituents.
4. Expanding of the database by accumulation of information on traditional medicines.

Thoughts on research

Quality of herbal drugs with multiple components varies depending on genetic and environmental factors. My theme is to stabilize the quality for providing the inherent effects of herbal drugs based on scientific evidences, including genetic, chemical and pharmacological data. Moreover, the studies to select value-added plants and to establish a cultivation method including post-harvest processing method have been conducted toward the development of branded herbal drugs.

Paper

Batsukh Z., Toume K., Javzan B., Kazuma K., Cai S. Q., Hayashi S., Kawahara N., Maruyama T., Komatsu K.: Metabolomic profiling of Saposhnikoviae Radix from Mongolia by LC-IT-TOF- MS/MS and multivariate statistical analysis. J. Nat. Med., 74: 170–188, 2020.
Doi: 10.1007/s11418-019-01361-0

Ge Y. W., Zhu S., Yoshimatsu K., Komatsu K.: MS/MS similarity networking accelerated target profiling of triterpene saponins in Eleutherococcus senticosus leaves. Food Chem., 227: 444-452, 2017.
Doi: 10.1016/j.foodchem.2017.01.119.

Kita T., Komatsu K., Zhu S., Iida O., Sugimura K., Kawahara N., Taguchi H., Masamura N., Cai S. Q.: Development of intron length polymorphism markers in genes encoding diketide-CoA synthase and curcumin synthase for discriminating Curcuma species. Food Chem., 194: 1329-1336, 2016.
Doi: 10.1016/j.foodchem.2015.08034.

Shi Y. H., Zhu S., Toume K., Wang Z., Batkhuu J., Komatsu K.: Characterization and quantification of monoterpenoids in different types of peony root and the related Paeonia species by liquid chromatography coupled with ion trap and time-of-flight mass spectrometry. J. Pharm. Biomed. Anal., 129: 581-592, 2016.
Doi: 10.1016/j.jpba.2016.07.031

Zhu S., Yu X. L., Wu Y. Q., Shiraishi F., Kawahara N., Komatsu K.: Genetic and chemical characterization of white and red peony root derived from Paeonia lactiflora. J. Nat. Med., 69: 35-45, 2015.
Doi: 10.1007/s11418-014-0857-5

keyword

Traditional medicines, Field investigation, Quality evaluation, Genetic polymorphisms, Cultivation of medicinal plants, Sustainability