Reserchers

YAMAMOTO Takeshi Assistant Professor

YAMAMOTO takeshi

AffiliationLaboratory of Gastrointestinal Disorder, Division of Presymptomatic Disease, Department of Research and Development

Research fieldsPharmacology, Immunology, Physiology

Campus careerPh.D.(Food and nutrition science)

Biography Academic Research Staff

Education

B. Sc. School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan.
Ph. D. Graduate Division of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka, Japan.

Job career

Assistant Professor, Faculty of Nursing and Nutrition, Siebold University of Nagasaki, Nagasaki, Japan
Assistant Professor, Institute of Natural Medicine, University of Toyama, Toyama, Japan.

Research theme

Department

Division

Section

Project

Outline of the research

The major aim in our laboratory is to clarify the pathogenesis and mechanisms underlying gastrointestinal disorders, especially enteric immune diseases using molecular biological, pharmacological, pathophysiological, immunological, morphological, and neurological techniques in the experimental models and cultured immune cells. Further, to integrate knowledge from experimental models to human diseases, our laboratory is engaged in the search for new seeds of the therapeutic medicines including Japanese traditional medicine (Kampo) and new concept of the therapeutic mechanisms based on our experiments.

1. Development of experimental models of the enteric immune diseases.
Our research focus is mainly on the investigation of food allergy and ulcerative colitis. These two enteric immune diseases have similar immunological profiles (Th2 related diseases in the whole-body immune system). There were few useful experimental models of these diseases and so the pathogenic mechanisms underlying these diseases remain poorly understood. Therefore, we are addressing the development of animal models for the translational research.

2. Clarification of the pathogenesis and mechanism underlying the enteric immune diseases.
We are investigating the enteric immune diseases mainly from the viewpoint of disruption of “enteric intranet” organized by the enteric immune system, enteric nervous system and enteric endocrine system.

3. Search for new seeds of the therapeutic medicine on the enteric immune diseases.
Until now, there is no useful and selective therapeutic medicine for the enteric immune diseases. To break an innovative medicine, our laboratory is searching for new seeds, particularly from kampo medicines.

Paper

The isoflavone puerarin induces Foxp3+ regulatory T cells by augmenting retinoic acid production, thereby inducing mucosal immune tolerance in a murine food allergy model.
Yamamoto T, Matsunami E, Komori K, Hayashi S, Kadowaki M.
Biochem Biophys Res Commun. Aug 27;516(3):626-631. doi: 10.1016/j.bbrc.2019.06.051.

Improvement of Therapeutic Efficacy of Oral Immunotherapy in Combination with Regulatory T Cell-Inducer Kakkonto in a Murine Food Allergy Model.
Nagata Y, Yamamoto T, Hayashi M, Hayashi S, Kadowaki M.
PLoS One. 2017 Jan 20;12(1):e0170577. doi: 10.1371/journal.pone.0170577.

Induction of Regulatory T Cells as a Novel Mechanism Underlying the Therapeutic Action of Kakkonto, a Traditional Japanese Herbal Medicine, in a Murine Food Allergy Model.
Yamamoto T, Fujiwara K, Tsubota Y, Kageyama-Yahara N, Hayashi S, Kadowaki M.
Int Arch Allergy Immunol. 2016;169(3):146-56. doi: 10.1159/000445433.

Anti-allergic role of cholinergic neuronal pathway via α7 nicotinic ACh receptors on mucosal mast cells in a murine food allergy model.
Yamamoto T, Kodama T, Lee J, Utsunomiya N, Hayashi S, Sakamoto H, Kuramoto H, Kadowaki M.
PLoS One. 2014 Jan 16;9(1):e85888. doi: 10.1371/journal.pone.0085888.

Oral tolerance induced by transfer of food antigens via breast milk of allergic mothers prevents offspring from developing allergic symptoms in a mouse food allergy model.
Yamamoto T, Tsubota Y, Kodama T, Kageyama-Yahara N, Kadowaki M.
Clin Dev Immunol. 2012;2012:721085. doi: 10.1155/2012/721085.

keyword

Food allergy, Oral immunotherapy, Kakkonto, Intestinal mucosal immunity, Regulatory T cells, Dendritic cells