富山大学 和漢医薬学総合研究所 生体防御学領域 がん・免疫ユニット

研究業績

2023年

  1. Lallo S, Hardianti B, Djabir YY, Ismail I, Indrisari M, Aswad M, Hertati A, Habibie H, Hayakawa Y. Piper retrofractum ameliorates imiquimod-induced skin inflammation via modulation of TLR4 axis and suppression of NF-κB activity. Heliyon. 9:e20151(2023) (Pubmed)
  2. Dung NT, Susukida T, Ucche S, He K, Sasaki SI, Hayashi R, Hayakawa Y. Calorie Restriction Impairs Anti-Tumor Immune Responses in an Immunogenic Preclinical Cancer Model. Nutrients. 15:3638.(2023) (Pubmed)
  3. Kobayashi E, Kamihara Y, Arai M, Wada A, Kikuchi S, Hatano R, Iwao N, Susukida T, Ozawa T, Adachi Y, Kishi H, Dang NH, Yamada T, Hayakawa Y, Morimoto C, Sato T. Development of a Novel CD26-Targeted Chimeric Antigen Receptor T-Cell Therapy for CD26-Expressing T-Cell Malignancies. Cells. 12:2059.(2023) (Pubmed)
  4. Susukida T, Sasaki SI, Shirayanagi T, Aoki S, Ito K, Hayakawa Y. Drug-induced altered self-presentation increases tumor immunogenicity. Biomed Pharmacother. 165:115241 (2023) (Pubmed)[プレスリリース]
  5. Seephan S, Sasaki SI, Wattanathamsan O, Singharajkomron N, He K, Ucche S, Kungsukool S, Petchjorm S, Chantaravisoot N, Wongkongkathep P, Hayakawa Y, Pongrakhananon V. CAMSAP3 negatively regulates lung cancer cell invasion and angiogenesis through nucleolin/HIF-1α mRNA complex stabilization. Life Sci. 322:121655.(2023) (Pubmed)
  6. Kikuchi S, Wada A, Kamihara Y, Okazaki K, Jawaid P, Rehman MU, Kobayashi E, Susukida T, Minemura T, Nabe Y, Iwao N, Ozawa T, Hatano R, Yamada M, Kishi H, Matsuya Y, Mizuguchi M, Hayakawa Y, Dang NH, Sakamoto Y, Morimoto C, Sato T. DPP8 Selective Inhibitor Tominostat as a Novel and Broad-Spectrum Anticancer Agent against Hematological Malignancies. Cells. 12:1100.(2023) (Pubmed)
  7. Boonyarat C, Tantiwatcharakunthon M, Takomthong P, Yenjai C, Hayakawa Y, Dejkriengkraikul P, Chaiwiwatrakul S, Waiwut P. Neuroprotective and anticancer effects of 7‑Methoxyheptaphylline via the TAK1 pathway. Oncol Rep. 49:15.(2023) (Pubmed)
  8. Ucche S, Yokoyama S, Mojic M, Oki K, Ohshima C, Tsuihiji H, Takasaki I, Tahara H, Hayakawa Y. GSTA4 Governs Melanoma Immune Resistance and Metastasis. Mol Cancer Res. 21:76-85.(2023) (Pubmed)[プレスリリース]

2022年

  1. Sabra RT, Abdellatef AA, Abdel-Sattar E, Fathy M, Meselhy MR, Hayakawa Y. Russelioside A, a Pregnane Glycoside from Caralluma tuberculate, Inhibits Cell-Intrinsic NF-κB Activity and Metastatic Ability of Breast Cancer Cells. Biol Pharm Bull. 45:1564-1571.(2022) (Pubmed)
  2. Yamada H, Sasaki SI, Tani H, Somekawa M, Kawasuji H, Saga Y, Yoshida Y, Yamamoto Y, Hayakawa Y, Morinaga Y. A novel hamster model of SARS-CoV-2 respiratory infection using a pseudotyped virus. Sci Rep. 12:11125.(2022) (Pubmed)
  3. Nakamura T, Kobayashi E, Hamana H, Hayakawa Y, Muraguchi A, Hayashi A, Ozawa T, Kishi H. Evaluation of chimeric antigen receptor of humanized rabbit-derived T cell receptor-like antibody. Cancer Sci. 113:3321-3329.(2022) (Pubmed)
  4. Gao WY, Boonyarat C, Takomthong P, Plekratoke K, Hayakawa Y, Yenjai C, Kaewamatawong R, Chaiwiwatrakul S, Waiwut P. Acridone Derivatives from Atalantia monophyla Inhibited Cancer Cell Proliferation through ERK Pathway. Molecules. 27:3865.(2022) (Pubmed)
  5. Do KM, Kodama T, Shin MK, Nu LHT, Nguyen HM, Dang SV, Shiokawa KI, Hayakawa Y, Morita H. Marginols A‒H, unprecedented pimarane diterpenoids from Kaempferia marginata and their NO inhibitory activities. Phytochemistry. 196:113109.(2022) (Pubmed)
  6. Lallo S, Hardianti B, Sartini S, Ismail I, Laela D, Hayakawa Y. Ethyl P-Methoxycinnamate: An Active Anti-Metastasis Agent and Chemosensitizer Targeting NFκB from Kaempferia galanga for Melanoma Cells. Life (Basel). 12:337.(2022) (Pubmed)
  7. Ozawa T, Tani H, Anraku Y, Kita S, Igarashi E, Saga Y, Inasaki N, Kawasuji H, Yamada H, Sasaki SI, Somekawa M, Sasaki J, Hayakawa Y, Yamamoto Y, Morinaga Y, Kurosawa N, Isobe M, Fukuhara H, Maenaka K, Hashiguchi T, Kishi H, Kitajima I, Saito S, Niimi H. Novel super-neutralizing antibody UT28K is capable of protecting against infection from a wide variety of SARS-CoV-2 variants. MAbs. 14:2072455.(2022) (Pubmed)

2021年

  1. Yokoyama S, Takahashi A, Kikuchi R, Nishibu S, Lo JA, Hejna M, Moon WM, Kato S, Zhou Y, Hodi FS, Song JS, Sakurai H, Fisher DE, Hayakawa Y. SOX10 regulates melanoma immunogenicity through an IRF4-IRF1 axis. Cancer Res. 81:6131-6141.(2021)(Pubmed)[プレスリリース]
  2. Sasaki SI, Di Z, Iwabuchi S, Tanabe Y, Hashimoto S, Yamauchi A, Hayashi K, Tsuchiya H, Hayakawa Y, Baba T, Mukaida N. Crucial contribution of GPR56/ADGRG1, expressed by breast cancer cells, to bone metastasis formation. Cancer Sci. 112(12):4883-4893.(2021) (Pubmed)
  3. Song B, Aoki S, Liu C, Susukida T, Kuwahara S, Ito K. The PD1 inhibitory pathway and mature dendritic cells contribute to abacavir hypersensitivity in human leukocyte antigen transgenic PD1 knockout mice. Toxicology. 463:152971.(2021) (Pubmed)
  4. Susukida T, Kuwahara S, Song B, Kazaoka A, Aoki S, Ito K. Regulation of the immune tolerance system determines the susceptibility to HLA-mediated abacavir-induced skin toxicity. Commun Biol. 4:1137. (2021)(Pubmed)[プレスリリース]
  5. Do KM, Shin MK, Kodama T, Win NN, Prema P, Nguyen HM, Hayakawa Y, Morita H. Flavanols and Flavanes from Crinum asiaticum and Their Effects on LPS Signaling Pathway Through the Inhibition of NF-κB Activation. Planta Med. (2021) ePub ahead of print(Pubmed)
  6. Mojic M, Shitaoka K, Ohshima C, Ucche S, Lyu F, Hamana H, Tahara H, Kishi H, Hayakawa Y. NKG2D defines tumor-reacting effector CD8+ T cells within tumor microenvironment. Cancer Sci. 112:3484-3490. (2021) (Pubmed)
  7. Beshay BY, Abdellatef AA, Loksha YM, Fahmy SM, Habib NS, Bekhit AEA, Georghiou PE, Hayakawa Y, Bekhit AA. Design and synthesis of 2-Substituted-4-benzyl-5-methylimidazoles as new potential Anti-breast cancer agents to inhibit oncogenic STAT3 functions. Bioorg Chem . 113:105033. (2021) (Pubmed)
  8. Abdellatef AA, Zhou Y, Yamada A, Elmekkawy SA, Kohyama A, Yokoyama S, Meselhy MR, Matsuya Y, Sakurai H, Hayakawa Y. Synthetic E-guggulsterone derivative GSD-1 inhibits NF-κB signaling and suppresses the metastatic potential of breast cancer cells. Biomed Pharmacother. 140:111737. (2021) (Pubmed)
  9. Abdellatef AA, Fathy M, Mohammed AEI, Bakr MSA, Ahmed AH, Abbass HS, El-Desoky AH, Morita H, Nikaido T, Hayakawa Y. Inhibition of cell-intrinsic NF-κB activity and metastatic abilities of breast cancer by aloe-emodin and emodic-acid isolated from Asphodelus microcarpus. J Nat Med. 75:840-853. (2021) (Pubmed)
  10. Shin MK, Sasaki F, Ki DW, Win NN, Morita H, Hayakawa Y. Identification of Ophiocordyceps gracilioides by Its Anti-tumor Effects through Targeting the NFκB-STAT3-IL-6 Inflammatory Pathway. Biol Pharm Bull. 44:686-690.　(2021) (Pubmed)
  11. Shin MK, Sasaki F, Ki DW, Win NN, Morita H, Hayakawa Y. Anti-metastatic effects of ergosterol peroxide from the entomopathogenic fungus Ophiocordyceps gracilioides on 4T1 breast cancer cells. J Nat Med. 75:824-832.(2021) (Pubmed)
  12. Umeyama L, Hardianti B, Kasahara S, Dibwe DF, Awale S, Yokoyama S, Hayakawa Y. Anti-inflammatory effects of Morus alba Linne bark on the activation of toll-like receptors and imiquimod-induced ear edema in mice. BMC Complement Med Ther. 21:115. (2021) (Pubmed)
  13. Pothongsrisit S, Arunrungvichian K, Hayakawa Y, Sritularak B, Mangmool S, Pongrakhananon V. Erianthridin suppresses non-small-cell lung cancer cell metastasis through inhibition of Akt/mTOR/p70 S6K signaling pathway. Sci Rep. 11:6618. (2021) (Pubmed)
  14. Fujiwara T, Miyazato K, Takahashi K, Hayakawa Y. Establishment of bioluminescent imaging model using murine T cell lymphoma susceptive to NK cell-dependent immune-surveillance. J Immunol Methods. 491:112993. (2021) (Pubmed)
  15. Fujimoto M, Kamiyama M, Fuse K, Ryuno H, Odawara T, Furukawa N, Yoshimatsu Y, Watabe T, Prchal-Murphy M, Sexl V, Tahara H, Hayakawa Y, Sato T, Takeda K, Naguro I, Ichijo H. ASK1 suppresses NK cell-mediated intravascular tumor cell clearance in lung metastasis. Cancer Sci. 112:1633-1643. (2021) (Pubmed)

2020年

  1. Umeyama L., Kasahara S., Sugawara M., Yokoyama S., Saiki I., Hayakawa Y. Anti‐inflammatory effect of fermented brown rice and rice bran with Aspergillus oryzae on mice. Tradit. Kampo Med. (2021) (Journal)
  2. Susmitha GD, Miyazato K, Ogura K, Yokoyama S, Hayakawa Y. Anti-metastatic Effects of Baicalein by Targeting STAT3 Activity in Breast Cancer Cells. Biol Pharm Bull. 43:1899-1905. (2020) (Pubmed)
  3. Hardianti B, Umeyama L, Li F, Yokoyama S, Hayakawa Y. Anti‑inflammatory compounds moracin O and P from Morus alba Linn. (Sohakuhi) target the NF‑κB pathway. Mol Med Rep. 22:5385-5391. (2020) (Pubmed)
  4. Yokoyama S, Iwakami Y, Hang Z, Kin R, Zhou Y, Yasuta Y, Takahashi A, Hayakawa Y, Sakurai H. Targeting PSMD14 inhibits melanoma growth through SMAD3 stabilization. Sci Rep. 10:19214. (2020) (Pubmed)
  5. Susukida T, Aoki S, Shirayanagi T, Yamada Y, Kuwahara S, Ito K. HLA transgenic mice: application in reproducing idiosyncratic drug toxicity. Drug Metab Rev. 52:540-567. (2020) (Pubmed)
  6. Miyazato K, Tahara H, Hayakawa Y. Anti-metastatic effects of thalidomide by inducing the functional maturation of peripheral NK cells. Cancer Sci. 111:2770-2778. (2020) (Pubmed)
  7. Miyazato K, Hayakawa Y. Pharmacological Targeting of Natural Killer Cells for Cancer Immunotherapy. Cancer Sci. 111:1869-1875. (2020) (Pubmed)
  8. Ucche S, Murwanti R, Ritmaleni, Hayakawa Y. Anti-metastatic effects of curcumin analogues in a mouse breast cancer model. BPB Reports. 3: 80-86 (2020) (Journal)
  9. Win NN, Hardianti B, Ngwe H, Hayakawa Y, Morita H. Anti-inflammatory activities of isopimara-8(9),15-diene diterpenoids and mode of action of kaempulchraols B-D from Kaempferia pulchra rhizomes. J Nat Med. 74:487-494. (2020) (Pubmed)
  10. Nwet Win N, Hardianti B, Kasahara S, Ngwe H, Hayakawa Y, Morita H. Anti-inflammatory activities of isopimara-8(14),-15-diene diterpenoids and mode of action of kaempulchraols P and Q from Kaempferia pulchra rhizomes. Bioorg Med Chem Lett. 30:126841. (2020) (PubMed)
  11. Xu X, Eshima S, Kato S, Fisher DE, Sakurai H, Hayakawa Y, Yokoyama S. Rational combination therapy for melanoma with dinaciclib by targeting BAK-dependent cell death. Mol Cancer Ther. 19:627-636. (2020) (PubMed)

2019年

  1. Takikawa A, Usui I, Fujisaka S, Tsuneyama K, Okabe K, Nakagawa T, Nawaz A, Kado T, Jojima T, Aso Y, Hayakawa Y, Yagi K, Tobe K. Macrophage-specific hypoxia-inducible factor-1α deletion suppresses the development of liver tumors in high-fat diet-fed obese and diabetic mice. J Diabetes Investig. 10:1411-1418. (2019) (PubMed)

2018年

  1. Iwakami Y, Yokoyama S, Watanabe K, Hayakawa Y. STAM-binding protein regulates melanoma metastasis through SLUG stabilization. Biochem Biophys Res Commun. 507:484-488. (2018) (PubMed)
  2. Yamamoto Y, Miyazato K, Takahashi K, Yoshimura N, Tahara H, Hayakawa Y, Lung-resident natural killer cells control pulmonary tumor growth in mice. Cancer Sci. 109:2670-2676. (2018) (PubMed)
  3. Watanabe K, Yokoyama S, Kaneto N, Hori T, Iwakami Y, Kato S, Hayakawa Y, Sakurai H, Fukuoka J, Saiki I. COP9 signalosome subunit 5 regulates cancer metastasis by deubiquitinating SNAIL. Oncotarget. 9:20670-20680. (2018) (PubMed)
  4. Shitaoka K, Hamana H, Kishi H, Hayakawa Y, Kobayashi E, Sukegawa K, Piao X, Lyu F, Nagata T, Sugiyama D, Nishikawa H, Tanemura A, Katayama I, Murahashi M, Takamatsu Y, Tani K, Ozawa T, Muraguchi A. Identification of Tumoricidal TCRs from Tumor-Infiltrating Lymphocytes by Single-Cell Analysis. Cancer Immunol Res. 6:378-388. (2018) (PubMed)
  5. Li L, Yokoyama S, Han N, Hayakawa Y. Lac water extract inhibits IFN-γ signaling through JAK2-STAT1-IRF1 axis in human melanoma. RSC Advances. 8: 21534–21540. (2018) (Journal)
  6. Ami N, Sato H, Hayakawa Y. Paclitaxel-induced hypothermia and hypoperfusion increase breast cancer metastasis and angiogenesis in mice. Oncol Lett. 15:2330-2334. (2018) (PubMed)
  7. Ogura K, Sato-Matsushita M, Yamamoto S, Hori T, Sasahara M, Iwakura Y, Saiki I, Tahara H, Hayakawa Y. NK cells control tumor-promoting function of neutrophils in mice. Cancer Immunol Res. 6:348-357. (2018) (PubMed)

2017年

  1. Endo S, Xia S, Suyama M, Morikawa Y, Oguri H, Hu D, Ao Y, Takahara S, Horino Y, Hayakawa Y, Watanabe Y, Gouda H, Hara A, Kuwata K, Toyooka N, Matsunaga T, Ikari A. Synthesis of Potent and Selective Inhibitors of Aldo-Keto Reductase 1B10 and Their Efficacy against Proliferation, Metastasis and Cisplatin Resistance of Lung Cancer Cells. J Med Chem. 60:8441-8455. (2017) (PubMed)
  2. Kamiyama M, Shirai T, Tamura S, Suzuki-Inoue K, Ehata S, Takahashi K, Miyazono K, Hayakawa Y, Sato T, Takeda K, Naguro I, Ichijo H. ASK1 facilitates tumor metastasis through phosphorylation of an ADP receptor P2Y12 in platelets. Cell Death Differ. 24:2066-2076. (2017) (PubMed)
  3. Xu X, Yokoyama S, Hayakawa Y, Saiki I. Coptidis Rhizoma induces intrinsic apoptosis through BAX and BAK activation in human melanoma. Oncol Rep. 38:538-544. (2017) (PubMed)
  4. Wu H, Tao A, Martin JD, Quader S, Liu X, Takahashi K, Hespel L, Miura Y, Hayakawa Y, Irimura T, Cabral H, Kataoka K. Proteasome Inhibitor-Loaded Micelles Enhance Antitumor Activity Through Macrophage Reprogramming by NF-κB Inhibition. J Pharm Sci. 106:2438-2446. (2017) (PubMed)
  5. Ma H, Yokoyama S, Saiki I, Hayakawa Y. Chemosensitizing Effect of Saikosaponin B on B16F10 Melanoma Cells. Nutr Cancer. 69:505-511. (2017) (PubMed)
  6. Takeda K, Nakayama M, Hayakawa Y, Kojima Y, Ikeda H, Imai N, Ogasawara K, Okumura K, Thomas DM, Smyth MJ. IFN-γ is required for cytotoxic T cell-dependent cancer genome immunoediting. Nat Commun. 8:14607. (2017) (PubMed)