|
Research outline of our lab.
Our laboratory focuses on two main themes.
Studies on the biosynthesis of bioactive compounds in natural resources such as Japanese crude drugs and Kampo medicines
- Investigation of enzymes involved in the biosynthesis of natural products and analysis of their catalytic mechanism based on X-ray crystal structure
- Engineering of biosynthetic enzymes to generate new compounds
- Production of useful compounds using heterologous expression system
Studies on naturally occurring bioactive substances in traditional medicines
- Discovery of anti-HIV agents that inhibit HIV-1 Vpr protein from natural resoureces and analysis of their inhibition mechanisms
- Discovery of anti-SmltD and SmltE agents that inhibit alternative peptideglycan biosynthesis of hospital infection-causing bacterium, Stenotrophomonas maltophilia, from natrual resourses
- Discovery of anti-inflammatory and anti-cancer agents from natural medicines and synthesis of their derivatives
- Investigation of traditional usage of natrual resources from a point of view of chemistry
Research Topics
|
RSS2.0