University of Toyama Institute of Natural Medicine English
  Research Staff Members Publications Field Investigation Links  


Shu ZHU, Ph. D. Shu ZHU, Ph. D.
Assistant Professor
Division of Pharmacognosy, Department of Medicinal Resources,
Institute of Natural Medicine, University of Toyama
2630 Sugitani, Toyama, 930-0194, Japan

Research interests

  1. Molecular systematic analysis on medicinal plants
  2. Authentication of herbal drugs and medicinal plants based on their genetic polymorphisms
  3. Quality evaluation of herbal drugs

List of Publications

36) Zhu S., Bai Y. J., Oya M., Tanaka K., Komatsu K., Maruyama T., Goda Y., Kawasaki T., Fujita M., Shibata T.: Genetic and chemical diversity of Eleutherococcus senticosus and molecular identification of Siberian ginseng by PCR-RFLP analysis based on chloroplast trnK intron sequence. Food Chemistry, 129: 1844-1850, 2011.
35) Kitani Y.,Zhu S., Batkhuu J., Sanchir C., Komatsu K.: Genetic diversity of Ephedra plants in Mongolia inferred from internal transcribed spacer sequence of nuclear ribosomal DNA. Biol. Pharm. Bull., 34: 717-726, 2011.
34) Rinthong P. O.,Zhu S., Komatsu K., Chanama S., De-Eknamkul W.: Genetic variation of Croton stellatopilosus Ohba based on non-coding DNA sequences of ITS, trnK and trnL-F regions. J. Nat. Med., 65: 641-645, 2011.
33) Bai Y. J., Tohda C., Zhu S., Hattori M., Komatsu K.: Active components from Siberian ginseng (Eleutherococcus senticosus) for protection of amyloid β(25-35)-induced neuritic atrophy in cultured rat cortical neurons. J. Nat. Med., 65: 417-423, 2011.
32) Hung T. M., Cuong T. D., Dang N. H., Zhu S., Long P. Q., Komatsu K., Min B. S. Flavonoid glycosides from Chromolaena odorata leaves and their in vitro cytotoxic activity. Chem. Pharm. Bull., 59:129-131, 2011.
31) Guo Z., Zou K., Dan F., Wang J., Zhu S., Komatsu K. Panajaponin, a new glycosphingolipid from Panax japonicus. Nat. Prod. Res., 24: 86-91, 2010.
30) Watthanachaiyingcharoen R., Komatsu K., Zhu S., Vajragupta O., Leelamanit W. Authentication of Coscinium fenestratum among the other menispermaceae plants prescribed in Thai folk medicines. Biol. Pharm. Bull., 33: 91-4. 2010.
29) Maruyama T., Kondo K., Yotsuyanagi Y., Yamamoto Y., Kawasaki T., Shiba M., Terasaki K., Yamane M., Zhu S., Skata K., Fujita M., Akiyama H., Nishimura N., Komatsu K., Mizukami H., Goda Y. The inter-laboratory validation study for the purity test of Atractylodes Rhizome targeted for Atractylodes Lancea Rhizome besed on PCR-RFLP. The Japanese Journal of Pharmacognosy, 64: 96-101, 2010.
28) Zhu S., Sugiyama R., Batkhuu J., Sanchir C., Zou K., Komatsu K. Survey of Glycyrrhizae Radix Resource in Mongolia: Chemical assessment on the underground part of Glycyrrhiza uralensis and comparison with Chinese Glycyrrhizea Radix. J. Nat. Med., 63:137-146, 2009.
27) Kitani Y., Zhu S., Omote T., Tanaka K., Batkhuu J., Sanchir C., Fushimi H., Mikage M., Komatsu K. Molecular analysis and chemical evaluation of Ephedra plants in Mongolia. Biol. Pharm. Bull., 7: 1235-1243, 2009.
26) Fan L. L.#, Zhu S.#(Co-1st author), Chen H. B., Yang D. H., Cai S. Q., Komatsu K. Molecular analysis of Stemona plants in China based on sequences of four chloroplast DNA regions. Biol. Pharm. Bull., 8: in press, 2009.
25) Fan L. L.#, Zhu S.#(Co-1st author), Chen H. B., Yang D. H., Cai S. Q., Komatsu K. Identification of the Botanical Source of Stemonae Radix Based on PCR with Specific Primers and PCR-RFLP. Biol. Pharm. Bull., 9: in press, 2009.
24) Zhu S., Fushimi H., Komatsu K.: Development of a DNA microarray for authentication of ginseng drugs based on 18S rRNA gene sequence. J. Agric. Food. Chem., 56: 3953-3959, 2008.
23) Liu H. Y., Zhu S., Komatsu K., Cai S. Q., Li Y. H., Yu C., Jiang Y., Sa Y.: Study on aqueous chemical constituents from the flower buds of Eugenia caryophylla. Zhong Yao Cai. 31: 998-1000, 2008.
22) Tohda C., Ichimura M., Bai Y., Tanaka K., Zhu S., Komatsu K.: Inhibitory effects of Eleutherococcus senticosus extracts on amyloid beta(25-35)-induced neuritic atrophy and synaptic loss. J. Pharmacol. Sci., 107: 329-339, 2008.
21) Zhu S., Fushimi H., Han G., Tsuchida T., Uno T., Takano A., and Komatsu K.: Molecular Identification of “Chuanxiong” by Nucleotide Sequence and Multiplex Single Base Extension Analysis on Chloroplast trnK Gene. Biol. Pharm. Bull., 30: 527-531, 2007.
20) Zou K., Komatsu K., and Zhu S.: A Novel Compound from Hedysarum polybotrys. J. Asian Nat. Prod. Res., 9: 481-485, 2007.
19) Tanaka K., Kubota M., Zhu S., Sankawa U., and Komatsu K.: Analysis of Ginsenosides in Ginseng Drugs Using Liquid Chromatography-Fourier Transform Ion Cyclotron Resonance Mass Spectrometry. Nat. Prod. Comm., 2: 625-632, 2007.
18) Sukrong S., Zhu S., Ruangrungsi N., Phadungcharoen T., Palanuvej C., and Komatsu K.: Molecular Analysis of the Genus Mitragyna Existing in Thailand Based on rDNA ITS Sequences and Its Application to Identify A Narcotic Species: Mitragyna speciosa. Biol. Pharm. Bull., 30: 1284-1288, 2007.
17) Komatsu K., Tohda C., and Zhu S.: Ginseng drugs - Molecular and Chemical Characteristics and Possibility as Antidementia Drugs. Current Topics in Nutraceutical Res., 3: 47-64, 2005.
16) Komatsu K., Zhu S., and Sasaki Y.: Systematic Pharmacognostical Study on Panax Drugs and Curcuma Drugs - Phylogenetic Analysis, Molecular Authentication and Quality Evaluation -. J. Trad. Med., 21: 251-270, 2004.
15) Zhu S., Zou K., Fushimi H., Cai S. Q., and Komatsu K.: Comparative Study on Triterpene Saponins of Ginseng Drugs. Planta Med., 70: 666-677, 2004.
14) Zhu S., Zou K., Cai S. Q., Meselhy M. R., and Komatsu K.: Simultaneous Determination of Triterpene Saponins in Ginseng Drugs by High Performance Liquid Chromatography. Chem. Pharm. Bull., 52: 995-998, 2004.
13) Zhu S., Fushimi H., Cai S. Q., and Komatsu K.: Species Identification from Ginseng Drugs by Multiplex Amplification Refractory Mutation System (MARMS). Planta Med., 70: 189-192, 2004.
12) Zhu S., Fushimi H., Cai S. Q., Chen H., and Komatsu K.: A New Variety of the Genus Panax from Southern Yunnan, China and Its Nucleotide Sequences of 18S Ribosomal RNA Gene and matK Gene. J. Jpn. Bot., 78: 86-94, 2003.
11) Zhu S., Fushimi H., Cai S. Q., and Komatsu K.: Phylogenetic Relationship in Genus Panax: Inferred from Chloroplast trnK Gene and Nuclear 18S rRNA Gene Sequences. Planta Med., 69: 647-653, 2003.
10) Tran Q. L., Than M. M., Tezuka Y., Banskota A. H., Kouda K., Watanabe H., Zhu S., Komatsu K., Thet M. M., Swe T., Maruyama Y., and Kadota S.: Wild Ginseng Grows in Myanmar. Chem. Pharm. Bull., 51: 679-682, 2003.
9) Zou K., Zhu S., Tohda C., Cai S. Q., and Komatsu K.:Dammarane-type triterpene saponins from Panax japonicus. J. Nat. Prod., 65: 346-351, 2002. *The material plant used in this study has been named as Panax vietnamensis var. fuscidiscus komatsu K, Zhu S. et Cai S.Q. based on genetic and chemical evidences. (referred to paper No. 13 above)
8) Zou K., Zhu S., Meselhy M. R., Tohda C., Cai S. Q., and Komatsu K.:Dammarane-type saponins from Panax japonicus and their neurite outgrowth activity in SK-N-SH cells. J. Nat. Prod., 65: 1288-1292, 2002.*The material plant used in this study has been named as Panax vietnamensis var. fuscidiscus komatsu K, Zhu S. et Cai S.Q. based on genetic and chemical evidences. (referred to paper No. 13 above)
7) Zou K., Zhu S., and Komatsu K. Analysis of Saponins of Panax Stipuleanatus by Using HPLC and APIMS/MS Techniques. J. China Three Gorges Univ. (Natural Sciences) 24(4): 355-357, (2002).
6) Komatsu K., Zhu S., Fushimi H., Qui T.K., Cai S.Q., and Kadota S.: Phylogenetic Analysis Based on 18S rRNA Gene and matK Gene Sequences of Panax vietnamensis and Five Related Species. Planta Med., 67: 461-465, 2001.
5) Ma C.M., Nakamura N., Hattori M., Zhu S., and Komatsu K.: Guaiane Dimers and Germacranolide from Artemisia caruifolia. J. Nat. Prod., 63: 1626-1627, 2000.
4) Cai S. Q., Zhu S. and Wang X., Macroscopic study on Chinese drug, Herba Asari. J. of China Pharmaceutical Univ. 1997. 28: 46-49.
3) Cai S. Q., Wang X., Zhu S., Li J. S., Lou Z. C., Namba T. and Komatsu K. Botanical origin of commercial samples of traditional Chinese drug xixin (Herba Aasari). China J. Chinese material Medica. 1996. 21: 712-717, 760.
2) Cai S. Q., Wang X., Zhu S. and Lou Z. C. Herbological study of Chinese traditional drug Xixin (Herba Asari). J. of Beijing Medical Univ. 1997, 29: 233-235.
1) Cai S. Q., Chen S. Z., Xie L. H. and Zhu S. The influence of plant age and collecting period on the volatile oil of Asarum heterotropoidies var. mandshuricum roots. J. Beijing Medical Univ. 1997, 29: 336-338, 371.
© Shoyaku Shigen Kagaku Bun'ya

Division of Pharmacognosy,
Institute of Natural Medicine, University of Toyama
2630 Sugitani, Toyama, 930-0194, Japan
TEL: 81-76-434-7601 / FAX: 81-76-434-5064
Institute of Natural Medicine
University of Toyama