Institute of Natural Medicine / University of Toyama


Research Outline

 

 We focus on pathophysiological molecular mechanisms underlying neurodegenerative diseases such as Alzheimer’s disease and spinal cord injury. Clarifying new mechanism for restoring neuritic dystrophy and synaptic loss leads to essential strategies toward overcoming functional deficits in neurodegeneration. Therefore, we aimed to develop and propose radical, ideal and epoch making therapeutic drugs that are able to reconstruct the neuronal network. In Alzheimer’s disease study, we found that several Kampo medicines and compounds derived from herbal drugs remarkably improved memory dysfunction in Alzheimer’s disease model mice. Those traditional medicine-derived compounds possibly show us novel signaling pathways that elicit reconstruction of the neuronal network. Also in spinal cord injury study, several effective drugs that ameliorate motor dysfunction and axonal growth have been discovered from traditional medicines. For example, Denosomin has multiple effects at least on neurons, astrocytes and microglia, resulting in conversion of their properties toward improvement of motor function. We are challenging to identify the multiple and novel mechanism by a variety of dynamic approaches. We practice “Traditional Medicine-based Drug Discovery” as original and useful approach that is done by integrating view of neuroscience and ethnomedicinal study.

 

                          

 

Resaerch Projects

  • 1. Integrative elucidation of the molecular mechanism of restoring the neuronal network in the central nervous system
    2. Research of essential therapeutic drugs for Alzheimer’s disease and spinal cord injury by “Traditional Medicine-based Drug Discovery” approach
    3. Identification of the molecular mechanism of failure in axonal regeneration in Alzheimer’s disease and spinal cord injury