富山大学 和漢医薬学総合研究所

原著

• [2023]

• ・Yang X. and Tohda C. Diosgenin restores memory function via SPARC-driven axonal growth from the hippocampus to the PFC in Alzheimer's disease model mice. Molecular Psychiatry (2023) in press
  
  ・Hosoi T, Yazawa K, Imada M, Tawara A, Tohda C, Nomura Y, Ozawa K. Alkannin attenuates amyloid β aggregation and Alzheimer's disease pathology. Mol Pharmacol. 2023 Mar 3;MOLPHARM-AR-2021-000468.
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  ・Inada Y. Tohda C. Causal Relationships between Daily Physical Activity, Physical Function, and Cognitive Function Ultimately Leading to Happiness. Int. J. Environ. Res. Public Health 2023, 20(4), 3016; https://doi.org/10.3390/ijerph20043016
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• ・Yang X. and Tohda C. Axonal Regeneration Mediated by a Novel Axonal Guidance Pair, Galectin-1 and Secernin-1. Mol Neurobiol. 2023 Mar;60(3):1250-1266. doi: 10.1007/s12035-022-03125-6.
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• ・Yang Z, Song C, Ge Y-W, Tohda C. Editorial: Treatment of Alzheimer's Disease-Discovery of Natural Products Based on Neurite Outgrowth and Neuroprotection. Frontiers in Pharmacology (2022) Nov 18;13:1079783.
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• 内山奈穂子，新井玲子，田中誠司，丸山卓郎，伊藤雅文，柴原豪了，武田修己，小栗志織，佐々木隆宏，岡　秀樹，白鳥　誠，秋田幸子，植村清美，浅野年紀，日向野太郎，杉本智潮，近藤誠三，吉田雅昭，西川加奈子，山田修嗣，山本　豊，玉木智生，木内文之，東田千尋，竹林憲司，小笠原勝，中村高敏，中川和也，横倉胤夫，神本敏弘，高尾正樹，高橋喜久美，高杉泰弘，岡坂　衛，佐々木　博，井川裕之，高谷和広，川原信夫，河野徳昭，袴塚高志. 局外生規2022新規収載単味生薬エキスの確認試験及び定量法の設定について. 生薬学雑誌 (2023) 77(1) 7-23.
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• [2022]

• ・Suyama M. Nagase-Iki T. and Tohda C.　New Evaluation Methods with High Sensitivity for Motor Function of the Ossification of the Posterior Longitudinal Ligament in ttw/ttw Mouse Model. Neurochemical J (2022) 16(2) 214-218.
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• ・Huang YH, Ding WL, Li XT, Cai MT, Li HL, Yang ZY, Piao XH, Zhu S, Tohda C, Komatsu K, Wang SM, Ge YW. Memory enhancement effect of saponins from Eleutherococcus senticosus leaves and blood-brain barrier-permeated saponins profiling using a pseudotargeted monitoring strategy. Food Funct. 2022 Mar 21;13(6):3603-3620.
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・Chino K, Izuo N, Noike H, Uno K, Kuboyama T, Tohda C, Muramatsu SI, Nitta A. Shati/Nat8l Overexpression Improves Cognitive Decline by Upregulating Neuronal Trophic Factor in Alzheimer's Disease Model Mice. Neurochem Res. 2022 Sep;47(9):2805-2814.

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• [2021]

• ・Nagase T, Tohda C. Skeletal muscle atrophy-induced hemopexin accelerates onset of cognitive impairment in Alzheimer's disease. J Cachexia, Sarcopenia and Muscle (2021) i12, 2199–2210.
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• ・Nakano A., Yang X., Kuboyama T., Inada Y., Tohda C. Intrathecal infusion of diosgenin during the chronic phase of spinal cord injury ameliorates motor function and axonal density. Neurochem J (2021) 15(4), 454-461.
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• ・de Toledo A, Nomoto K, Hirano E, Tohda C. Horse Placental Extract Enhances Neurogenesis in the Presence of Amyloid β. Nutrients 2021, 13(5), 1672. doi.org/10.3390/nu13051672
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• ・Farid MM, Nagasea T, Yang X, Nomoto N, Kuboyama T, Inada Y, Tohda C. Effects of Trigonella foenum-graecum seeds extract on Alzheimer's disease transgenic model mouse and its potential active compound transferred to the brain. 日本食品化学学会誌 Japanese Journal of Food Chemistry and Safety (2021) 28(2) 63-70.
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• ・Tohda C., Nomoto K. Kogure C., de Toledo A., Yang X., Hirano E. A novel heptapeptide, GPPGPAG transfers to the brain, and ameliorates memory dysfunction and dendritic atrophy in Alzheimer’s disease model mice. Frontiers in Pharmacology (2021) 12, 680652, doi: 10.3389/fphar.2021.6806527.
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• ・Inada Y., Tohda C., Yang X. Effects of Cistanche tubulosa Wight Extract on Locomotive Syndrome: A Placebo-Controlled, Randomized, Double-Blind Study. Nutrients (2021) 13, 264.doi:https://doi.org/10.3390/nu13010264.

 

• ・Kuboyama T, Kominato S, Nagumo M, Tohda C. Recovery from spinal cord injury via M2 microglial polarization induced by Polygalae Radix Phytomedicine. Phytomedicine. (2021)　82, 153452.

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• [2020]

• ・Kikuchi T, Tohda C, Suyama M. Recovery of motor function of chronic spinal cord injury by extracellular pyruvate kinase isoform M2 and the underlying mechanism.Sci Rep. 2020;10(1):19475. doi: 10.1038/s41598-020-76629-7.
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• ・Yang X, Nomoto K, Tohda C. Diosgenin content is a novel criterion to assess memory enhancement effect of Yam extracts. Journal of Natural Medicines (2020)　
  
• ・Farid M.M., Yang X., Kuboyama T., Tohda C. Trigonelline recovers memory function in Alzheimer’s disease model mice: Evidence of brain penetration and target molecule. Scientific Reports (2020) 10, 16424.
• ・Tohda C, Yang X, Nomoto K. Transported amount of diosgenin to the brain is differed by a solvent fat. 日本食品化学学会誌 (2020)　27(2), 102-105.
• ・Tanie Y, Kuboyama T, Tohda C. GRP78-mediated signaling contributes to axonal growth resulting in motor function recovery in spinal cord-injured mice. Frontiers in Pharmacology (2020) 11, 789; doi: 10.3389/fphar.2020.00789.
• ・Tohda C, Matsui M, Inada Y, Yang X, Kuboyama T, Kimbara Y, Watari H. Combined treatment with two water extracts of Eleutherococcus senticosus leaf and rhizome of Drynaria fortunei enhances cognitive function: a placebo-controlled, randomized, double-blind study in healthy adults. Nutrients (2020) 12, 303; doi: 10.3390/nu12020303.
• ・内山奈穂子，増本直子，丸山卓郎，合田幸広，袴塚高志，山本豊，玉木智生， 中田孝之，山田修嗣，伊藤雅文，若林健一，武田修己，小栗志織，佐々木隆宏， 岡秀樹，白鳥誠，秋田幸子，植村清美，塩本秀己，浅野年紀，日向野太郎， 須藤慶一，近藤誠三，西川加奈子，木内文之，東田千尋，竹林憲司，中村高敏， 西尾雅世，中川和也，横倉胤夫，神本敏弘，田辺章二，土屋久美，高尾正樹，高 橋喜久美，松本和弘，嶋田康男，佐々木博，川原信夫．局外生規2018に新規収載された単味生薬エキスの確認試験及び定量法の設定について．生薬学雑誌 (2020) 74(1), 20-34.

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• [2019]

• ・Kimbara Y, Shimada Y, Kuboyama T, Tohda C.
  Cistanche tubulosa (Schenk) Wight extract enhances hindlimb performance and attenuates myosin heavy chain IId/IIx expression in cast-immobilized mice. Evidence-Based Complementary and Alternative Medicine (2019) Article ID 9283171.
• ・Yamauchi A, Tone T, Sugimoto K, Lim HS, Kaku T, Tohda C, Shindo T, Tamada K, Mizukami Y, Hirano E.
• Porcine placental extract facilitates memory and learning in aged mice. Food Science & Nutrition (2019) 7, 2995-3005. Doi:10.1002/fsn3.1156 (2019 9)
• ・Yamauchi Y, Ge. Y-W, Yoshimatsu K, Komatsu K, Kuboyama T, Yang X, Tohda C. Memory ehancement by oral administration of extract of Eleutherococcus senticosus leaves and active compounds transferred in the brain. Nutrients, (2019) 11, 1142.
• ・Watari, H, Shimada Y, Matsui M, Tohda C.
• Kihito, a traditional Japanese Kampo medicine, improves cognitive function in Alzheimer’s disease patients. eCAM (2019) Article ID 2019: 4086749.
• ・Tanabe N., Kuboyama T., Tohda C.
• Matrine promotes neural circuit remodeling to regulate motor function in a chronic model of spinal cord injury. Neural Regen. Res., (2019) 14(11):1961-1967.
• ・Yang Z., Kuboyama T., Tohda C. Naringenin promotes microglial M2 polarization and Aβ degradation enzyme expression. Phytother Res, (2019). 33(4):1114-1121.

• ・Kodani A, Kikuchi T, Tohda C. Acteoside improves muscle atrophy and motor function by inducing  new myokine secretion in chronic spinal cord injury. J Neurotrauma (2019) 36(12):1935-1948.

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  [2018]
  
• ・Tanie Y, Tanabe N, Kuboyama T, Tohda C. Extracellular neuroleukin enhances neuroleukin secretion from astrocytes and promotes axonal growth in vitro and in vivo. Frontiers in Pharmacology (2018) 9:1228. 
  
• ・Yang X, Tohda C. Diosgenin restores Aβ-induced axonal degeneration by reducing the expression of heat shock cognate 70 (HSC70).  Scientific Reports (2018)  8(1):11707.
• ・Tanabe N, Kuboyama T, Tohda C. Matrine Directly Activates Extracellular Heat Shock Protein 90, Resulting in Axonal Growth and Functional Recovery in Spinal Cord Injured-mice. Frontiers in Pharmacology (2018) 9:446.
• ・Yang X, Tohda C. Heat Shock Cognate 70 inhibitor, VER-155008, reduces memory deficits and axonal degeneration in a mouse model of Alzheimer’s disease. Frontiers in Pharmacology (2018) 9:48.

・Sakamoto I, Ueyama T, Hayashibe M, Nakamura T, Mohri H, Kiyonari H, Shigyo M, Tohda C, Saito N. Roles of Cdc42 and Rac in Bergmann glia during cerebellar corticogenesis. Exp. Neurol. (2018) 302:57-67.

 

[2017]

• ・Tohda C, Tohda M. Extracellular cathepsin L stimulates axonal growth in neurons. BMC Research Note (2017) 10:613.
• ・Kuboyama T, Hirotsu K, Arai T, Yamasaki H, Tohda C. Polygalae Radix extract prevents axonal degeneration and memory deficits in a transgenic mouse model of Alzheimer’s disease.  Frontiers in Pharmacology (2017)(2017) 8, 805.
• ・Tohda C, Yang X, Matsui M, Inada Y, Kadomoto E, Nakada S, Watari H, Shibahara N. Diosgenin-Rich Yam Extract Enhances Cognitive Function: A Placebo-Controlled, Randomized, Double-Blind, Crossover Study of Healthy Adults. Nutrients (2017) 9(10), 1160; doi:10.3390/nu9101160   (24 October 2017)
• ・Kobayashi R, Tohda C. Extracellular Cytosolic Aspartate Aminotransferase Promotes Axonal Growth and Object Recognition Memory. Neurochem Res. (2017) doi: 10.1007/s11064-017-2394-6. (Aug 29.)

・Kogure C, Tohda C. Human placenta extract ameliorates memory dysfunction and dendritic atrophy in a 5XFAD mouse model of Alzheimer’s disease. Traditional & Kampo Medicine,(2017) 4(2):94-104.

• ・Yang Z, Kuboyama T, Tohda C A systematic strategy for discovering a therapeutic drug for Alzheimer’s disease and its target molecule. Frontiers in Pharmacology (2017) 8, 340. doi: 10.3389/fphar.2017.00340.
• ・Ishii T, Ueyama T, Shigyo M, Kohta M, Kondoh T, Uebi T, Kuboyama T, Gutmann DH, Aiba A, Kohmura E, Tohda C, Saito N. A Novel Rac1-GSPT1 Signaling Pathway Controls Astrogliosis Following Central Nervous System Injury. J. Biol. Chem. (2017) 292(4):1240-1250. doi: 10.1074/jbc.M116.748871.
  
• [2016]
• ・Ge YW, Tohda C, Zhu S, He YM, Yoshimatsu K, Komatsu K.　Effects of Oleanane-Type Triterpene Saponins from the Leaves of Eleutherococcus senticosus in an Axonal Outgrowth Assay.　J Nat Prod. (2016) 79(7):1834-1841. doi: 10.1021/acs.jnatprod.6b00329.
  
• ・Shigyo M, Tohda C. Extracellular vimentin is a novel axonal growth facilitator for functional recovery in spinal cordinjured mice. Scientific Reports (2016) 6:28293. doi:10.1038/srep28293.
  ・Tanabe N, Kuboyama T, Kazuma K, Konno K, Tohda C.The extract of roots of Sophora flavescens enhances the recovery of motor function by axonal growth in mice with a spinal cord injury. Frontiers in Pharmacology (2016) 6:326. doi: 10.3389/fphar.2015.00326.

• ・Sugimoto K, Yajima H, Hayashi Y, Minato D, Terasaki S, Tohda C, Matsuya Y. Synthesis of Denosomin-Vitamin D3 Hybrids and Evaluation of their Anti-Alzheimer’s Disease Activities. Organic Lett. (2015) 17(23):5910-5913. doi: 10.1021/acs.orglett.5b03138.
• ・Watari H, Shimada Y, Tohda C. Cytosolic aspartate aminotransferase, a direct binding protein of kamikihito, regulates axon growth. Traditional Kampo Medicine (2016) 3, 41-49. DOI: 10.1002/tkm2.1037
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[2015]

• ・Yang Z, Kuboyama T, Kazuma K, Konno K, Tohda C. Active constituents from Drynaria fortune Rhizomes on the attenuation of Aβ25-35-induced axonal atrophy. J Natural Products (2015) 78(9):2297-2300. doi: 10.1021/acs.jnatprod.5b00290.

• ・Shigyo M, Kuboyama T, Sawai Y, Tada-Umezaki M, Tohda C.　Extracellular vimentin interacts with insulin-like growth factor 1 receptor to promote axonal growth. Scientific Reports (2015) 5:12055. Doi:10.1038/srep12055.
• ・Kuboyama T, Lee Y-A, Nishiko H, Tohda C. Inhibition of clathrin-mediated endocytosis prevents amyloid β-induced axonal damage. Neurobiology of Aging (2015) 36(5):1808-1819.
• ・Watari H, Shigyo M, Tanabe N, Tohda M, Cho K-H, Kyung P-S, Jung W-S, Shimada Y, Shibahara N, Kuboyama T, Tohda C. Comparing the effects of kamikihito in Japan and kami-guibi-tang in Korea on memory enhancement: working toward the development of a global study. Phytother Res (2015) 29(3):351-356. doi: 10.1002/ptr.5250.

[2014]

• ・Shigyo M, Tanabe N, Kuboyama T, Choi SH, Tohda C. New reliable scoring system, Toyama Mouse Score, to evaluate locomotor function following spinal cord injury in mice. BMC Research Note (2014) 2014 Jun 3;7:332. doi: 10.1186/1756-0500-7-332.

・Watari H, Shimada Y, Tohda C. New treatment for Alzheimer’s disease, kamikihito, reverses amyloid-ß-induced progression of tau phosphorylation and axonal atrophy. Evidence-Based Complementary and Alternative Medicine, Volume 2014 (2014), Article ID 706487

 

[2013]

・Zhang H-Y, Yamakawa Y , Matsuya Y , Toyooka N, Tohda C, Awale S, Li F, Kadota S, Tezuka Y Synthesis of long-chain fatty acid derivatives as a novel anti-Alzheimer's agent.　 Bioorganic & Medicinal Chemistry Letters, (2013) Dec 9. pii: S0960-894X(13)01380-2.

・Tohda C, Lee Y-A, Goto Y, Nemere I. Diosgenin-induced cognitive enhancement in normal mice is mediated by 1,25D3-MARRS.　Scientific Reports,(2013) Dec 2;3:3395.

・Kuboyama T, Luo X, Park K, Blackmore M.G, Tojima T, Tohda C, Bixby J.L, Lemmon V.P, Kamiguchi H. Paxillin phosphorylation counteracts proteoglycan-mediated inhibition of axon regeneration.　Experimental Neurology, (2013) 248:157-169.

・Sugimoto K, Tamura K, Tohda C, Toyooka N, Nemoto H, Matsuya Y. Structure-activity-relationship studies on dihydrofuran-fused perhydrophenanthrenes as an anti-Alzheimer's disease agent.　Bioorganic & Medicinal Chemistry, (2013) 21: pp. 4459-4471.

・Teshigawara K, Kuboyama T, Shigyo M, Nagata A, Sugimoto K, Matsuya Y, Tohda C. A novel compound, Denosomin ameliorates spinal cord injury via axonal growth associated with astrocyte-secreted vimentin” Br. J. Pharmacol. (2013) 168(4): 903-919.

 

[2012]

・Tohda C, Urano T, Umezaki M, Nemere I, Kuboyama T. Diosgenin is an exogenous activator of 1,25D3-MARRS/Pdia3/ERp57 and improves Alzheimer’s disease pathologies in 5XFAD mice” Sci. Rep., (2012) 2, 535.

・ Tohda C, Nagata A. Epimedium koreanum extract and its constituent icariin improve motor dysfunction in spinal cord injury. Evidence Based Complementary and Alternative Medicine (2012) 2012:731208.

・ Wang X-H, Zhu H, Konno K, Tohda C, Kazuma K, Kuboyama T, Miyanaga S. Screening of fractions from some Chinese herbs for spinal cord injury. Chinese Journal of Experimental Traditional Medical Formulae, (2012) 18(12):246-248.

・Sugimoto K, Tamura K, Ohta N, Tohda C, Toyooka N, Nemoto H, Matsuya Y. Synthesis of dihydrofuran-fused perhydrophenanthrenes having a phenolic hydroxyl group as a novel anti-Alzheimer's disease agent. Bioorganic & Medicinal Chemistry Letters, (2012) 22, 449-452.

 

[2011]

・ Tohda C, Nakada R, Urano T, Okonogi A, Kuboyama T. Kamikihi-to (KKT) rescues axonal and synaptic degeneration associated with memory impairment in a mouse model of Alzheimer’s disease, 5XFAD. Int. J. Neurosci., (2011) 121, 641-648.

・ Bai Y, Tohda C, Zhu S, Hattori M, Komatsu K.　Active components from Siberian ginseng (Eleutherococcus senticosus) for protection of amyloid β(25-35)-induced neuritic atrophy in cultured rat cortical neurons.　J. Nat. Med. （2011） 65, 417-423. (2011, 7)

・ Joyashiki E., Matsuya Y., Tohda C. Sominone improves memory impairments and increases axonal density in Alzheimer’s disease model mice, 5XFAD. Int. J. Neurosci., (2011) 121, 181-190. (2011, 4)

 

[- 2010]

・ Urano T., Tohda C. Icariin improved memory impairment in Alzheimer’s disease model mice (5XFAD) and attenuates amyloid β-induced neurite atrophy. Phytother. Res., (2010) 24, 1658-1663. (2010, 11)

・ Prangsaengtong O., Koizumi K., Senda K., Urano T., Nagata A., Sakurai H., Tohda C., Saiki I. Methanol extract of Polygonati Rhizoma enhances the tube formation of rat lymphatic endotherial cells. J. Trad. Med. (2010) 27, 59-65.　　2010/4

・ Matsuya Y., Yamakawa Y., Tohda C., Teshigawara K., Yamada M. and Nemoto H. Synthesis of Sominone and Its Derivatives Based on RCM Strategy: Discovery of A Novel Anti-Alzheimer’s Disease Medicine Candidate “Denosomin”. Org. Lett. (2009) 11, 3970-3973.

・Tohda C., Joyashiki E. Sominone enhances neurite outgrowth and spatial memory mediated by the neurotrophic factor receptor, RET. British Journal of Pharmacology (2009) 157, 1427-1440.

・ Tohda C., Naito R., Joyashiki E. Kihi-to, a herbal traditional medicine, improves Abeta(25-35)-induced memory impairment and losses of neurites and synapses. BMC Complementary and Alternative Medicine (2008) 8;49.

・ Tohda C., Ichimura M., Bai Y., Tanaka K., Zhu S., Komatsu K. Inhibitory effects of Eleutherococcus senticosus extracts on amyloid beta(25-35)-induced neuritic atrophy and synaptic loss. Journal of Pharmacological Sciences (2008) 107, 329-339.

・ Tohda C., Nakanishi R., and Kadowaki M. Hyperactivity, memory deficit and anxiety-related behaviors in mice lacking the p85? subunit of phosphoinositide-3 kinase. Brain & Development (2009) 31, 69-74.

・ Tohda C., Nakanishi R., and Kadowaki M. Learning-deficits and agenesis of synapses and myelinated axons in phosphoinositide-3 kinase-deficient mice. Neurosignals (2007) 15, 293-306.

・ Sasaki S., Tohda C., Kim M., and Yokozawa T. gamma-Aminobutyric acid specifically inhibits progression of tubular fibrosis and atrophy in nephrectomized rats. Biol. Pharm. Bull. (2007) 30, 687-691.

・ Nakayama N. and Tohda C. Withanoside IV improves hindlimb function by facilitating axonal regrowth and increase in peripheral nervous system myelin level after spinal cord injury. Neurosci. Res. (2007) 58, 176-182.

・ Tohda C., Tamura T., Matsuyama S. and Komatsu K. Promotion of axonal maturation and inhibition of dementia by Astragalus mongholicus. British. J. Pharmacol., (2006) 149, 532-541.

・ Naito R. and Tohda C. Characterization of anti-neurodegenerative effects of Polygala tenuifolia in Abeta(25-35)-treated cortical neurons. Biol.Pharm. Bull., (2006) 29, 1892-1896.

・ Kuboyama T., Tohda C. and Komatsu K. Withanoside IV and its active metabolite, sominone, attenuate Abeta(25-35)-induced neurodegeneration. Eur. J. Neurosci (2006) 23, 1417-1427.

・ Tohda C., Nakayama N., Hatanalka F. and Komatsu K. Comparison of anti-inflammatory activities of six Curcuma rhizomes: a possible curcuminoid-independent pathway mediated by Curcuma phaeocaulis extract. Evidence-based Complementary and Alternative Medicine (2006) 3, 255-260.

・ Fujii H.,Yokozawa T., Kim Y.A., Tohda C., Nonaka G. Protective effect of grape seed polyphenols against high glucose induced-oxidative stress. Biosci.. Biotech. Biochem. (2006) 70, 2104-2111.

・Kim H.J., Yokozawa T., Kim H.Y., Tohda C., Rao T.P. and Juneja L.R. Influence of Amla (Emblica officinalis Gaertn.) on Hypercholesterolemia and Lipid Peroxidation in Cholesterol-Fed Rats. J. Nutr. Sci. Vitaminol. (2005) 51, 413-418.

・ Tohda C., Hashimoto I., Kuboyama T. and Komatsu K. Metabolite 1 of protopanaxadiol-type saponins, an axonal regenerative factor, stimulates teneurin-2 linked by PI3-kinase cascade. Neuropsychopharmacology (2006) 31, 1158-1164.

・ Kuboyama T., Tohda C. and Komatsu K. Neuritic regeneration and synaptic reconstruction induced by withanolide A. British J. Pharmacol. (2005) 144, 961-971.

・ Tohda C., Matsumoto N., Zou K., Meselhy R. M. and Komatsu K. Abeta(25-35)-induced memory impairment, axonal atrophy and synaptic loss are ameliorated by M1, a metabolite of protopanaxadiol-type saponins. Neuropsychopharmacology (2004) 29, 860-868.

・ Tohda C.,Tamura T. and Komatsu K. Repair of amyloid beta(25-35)-induced memory impairment and synaptic loss by a Kampo formula, Zokumei-to. Brain Res. (2003) 990, 141-147.

・ Sasaki Y., Goto H., Tohda C., Hatanaka F., Shibahara N., Shimada Y., Terasawa K. and Komatsu K. Effects of Curcuma drugs on vasomotion in isolated rat aorta. Biol. Pharm. Bull. (2003) 26, 1135-1143.

・ Tohda C. Comprehensive identifying method for localized mRNAs in single neuronal axons. J. Biochem. Biophys. Methods (2003) 57, 57-63.

・ Tohda C., Matsumoto N., Zou K., Meselhy R.M. and Komatsu K. Axonal and dendrite extension by protopanaxadiol-type saponins from Ginseng drugs in SK-N-SH cells. Jpn. J. Pharmacol. (2002) 90, 254-262.

・Zou K., Zhu S., Meselhy R. M., Tohda C., Cai S. and Komatsu K. Dammarane-type saponins from Panax japonicus and their neurite outgrowth activity in SK-N-SH cells. J. Natural Products (2002) 65, 1288-1292.

・ Kuboyama T., Tohda C., Zhao J., Nakamura N., Hattori M. and Komatsu K. Axon- or dendrite-predominant outgrowth induced by constituents from Ashwagandha. NeuroReport (2002) 13, 1715-1720.

・ Zhao J., Nakamura N., Hattori M., Kuboyama T., Tohda C. and Komatsu K. Five new withanolide derivatives from the roots of Withania somnifera. Chem. Pharm. Bull. (2002) 50, 760-765.

・ Zou K., Zhu S., Tohda C., Cai S. and Komatsu K. Dammarane-type triterpene saponins from Panax japonicus. J. Natural Products (2002) 65, 346-351.

・ Basnet P., Yasuda I., Kumagai N., Tohda C., Nojima H., Kuraishi Y. and Komatsu K. Inhibition of Itch-scratch response by fruits of Cnidium monnieri In mice. Biol. Pharm. Bull. (2001) 24, 1012-1015.

・ Tohda C., Sasaki M., Konemura T., Sasamura T., Itoh M. and Kuraishi Y. Axonal transport of VR1 capsaicin receptor mRNA in primary afferents and its participation in inflammation-induced increase in capsaicin sensitivity. J. Neurochem. (2001) 76, 1628-1635.

・ Tohda C., Kuboyama T. and Komatsu K. Dendrite extension by methanol extract of Ashwagandha (roots of Withania somnifera) in SK-N-SH cells. NeuroReport (2000) 11, 1981-1985.

・Tohda C., Sugahara H., Kuraishi Y. and Komatsu K. Inhibitory effect of Byakko-ka-ninjin-to on itch in a mouse model of atopic dermatitis. Phytother. Res. (2000) 14, 192-194.

・ Tohda C., Kakihara Y., Komatsu K. and Kuraishi Y. Inhibitory Effects of Methanol Extracts of Herbal Medicines on Substance P-Induced Itch-Scratch Response. Biol. Pharm. Bull. (2000) 23, 599-601.

・ Tohda C. and Jacobowitz D.M. The function and expression of sproutin, a novel neurite outgrowth factor. NeuroReport (1999) 10, 2089-2094.

・ Tohda C., Nakamura N., Komatsu K. and Hattori M. Trigonelline-induced neurite outgrowth in human neuroblastoma SK-N-SH cells. Biol. Pharm. Bull. (1999) 22, 679-682.

・ Sasamura T., Sasaki M., Tohda C., Kuraishi Y. Existence of capsaicin-sensitive glutamatergic terminals in rat hypothalamus. NeuroReport (1998) 9, 2045 - 2048.

・ Sasaki M., Tohda C., Kuraishi Y. Region-specific increase in glutamate release from dorsal horn of rats with adjuvant inflammation. NeuroReport (1998) 9, 3219-3222.

・ Tohda C., Yamaguchi T., and Kuraishi Y. Increased expression of mRNA for myocyte-specific enhancer binding factor (MEF) 2C in the cerebral cortex of itching mouse. Neurosci. Res. (1997) 29, 209-215.

・ Tohda C., Yamaguchi T. and Kuraishi Y. Intracisternal injection of opioids induces itch-associated response through ??opioid receptors in mice. Jpn. J. Pharmacol. (1997) 74, 77-82.

・ Andoh T., Tohda C. and Kuraishi Y. Analysis of dissociated single neurons by simple and semi-quantitative RT-PCR (reverse transcription and polymerase chain reaction). Jpn. J. Pharmacol. (1997) 74, 121-123.

・ Tohda C. and Kuraishi Y. Visualization of glutamate from rat spinal cord with a confocal laser scanning microscope. Neurosci. Res. (1996) 24, 183-187.

・ Tohda C., Nagai S., Kuraishi Y. and Nomura Y. Expression of mRNA for a neuronal differentiation factor, TA20, in developing rat brains. Neurosci. Res. (1996) 24, 421-425.

・ Tohda C., Nagai S., Tohda M. and Nomura Y. A novel factor, TA20, involved in neuronal differentiation; cDNA cloning and expression. Neurosci. Res. (1995) 23, 21-27.

・ Tohda M., Tohda C., Oda H. and Nomura, Y. Possible involvement of botulinum ADP-ribosyltransferase sensitive low molecular G protein on 5-HT-induced inositol phosphates formation in 5-HT2C cDNA transfected cells. Neurosci. Lett. (1995) 190, 33-36.

・ Tohda M., Tohda C., Sakuma S., Higashida H. and Nomura Y. Distinct induction of c-fos mRNA in NG108-15 cells transfected with muscarinic m1 and m3 receptors. Eur. J. Pharmacol. (1994) 268, 169-176.

・ Kumagai-Tohda C., Tohda M., and Nomura Y. Increase in neurite formation and acetylcholine release by transfection of GAP-43 cDNA into NG108-15 cells. J. Neurochem. (1993) 61, 526-532.

・ 東田道久、東田千尋、眞鍋いづみ、丹代優香、清水岑夫、宮一諭起範、宮森毅、野村靖幸、　黄?関連フラボノイドの中枢作用とその情報伝達機構。　和漢医薬学会誌　(1993) 10, 179-185.

・ Kumagai C., Tohda M. and Nomura Y. Involvement of growth-associated protein-43 with irreversible neurite outgrowth by dybutyryl cyclic AMP and phorbol ester in NG108-15 cells. J. Neurochem. (1992) 59, 41-47.

・ Tohda M., Kumagai C. and NomuraY. Effects of the simultaneous application of dibutyryl cAMP and phorbol ester on morphological differentiation in NG108-15 cells. Neurochem. Int. (1991) 19, 255-260.

 

研究業績 (総説・著書・その他）

総説

• ・Tohda C． New age therapy for Alzheimer’s disease by neuronal network reconstruction. Biol Pharm Bull (2016) 39(10), 1569-1575.  Doi: 10.1248/bpb.b16-00438
  
• ・東田千尋、渡り英俊、　アルツハイマー病の記憶障害を改善する帰脾湯・加味帰脾湯． 日本薬理学雑誌 (2015) 145, 224-228. http://plaza.umin.ac.jp/JPS1927/fpj/issue/TOC15-145(4)/15-145-4.htm    2015/4/1
  
• ・東田千尋、久保山友晴、　伝統薬物研究が薬理学にもたらす新しい視点． 日本薬理学雑誌 (2014) 143, 73-77. http://plaza.umin.ac.jp/JPS1927/fpj/issue/TOC14-143(2)/14-143-2.htm    2014/2/1
  
• ・Kuboyama T., Tohda C., Komatsu K. Effects of Ashwagandha (roots of Withania somnifera Dunal) on neurodegenerative diseases. Biol Pharm Bull (2014) 37(6):892-897.

• 東田千尋、薬用植物の多彩な作用点を明らかにする―新しい薬効機序発見への糸口―．　実験医学 News & Hot Paper (2014) 32(3), 416-417.   2014/2/1
  https://www.yodosha.co.jp/jikkenigaku/nhpd/9784758101240/c1.html
  

• ・ Tohda C., Kuboyama T. Current and future therapeutic strategies for functional repair of spinal cord injury. Pharmacology & Therapeutics (2011) 132, 57-71.

  ・ Tohda C., Potential of traditional medicine-derived compounds as therapeutic drugs for Alzheimer’s diseases. Basics of Evidences-Based Herbal Medicine. Research Signpost/Transworld Research Network. Kerala, India. (2010) 89-104.

  ・ 東田千尋、アルツハイマー病に有効な漢方薬 漢方と最新治療 (2009) 18, 167-172. .

  ・ 東田千尋、伝統薬物による神経変性疾患の克服　−治療薬開発と病態機序の解明に向けて−. 薬学雑誌 (2008) 128, 1159-1167.

  ・5) 小松かつ子、佐々木陽平、東田千尋、田中謙 鬱金類生薬の基原と品質. Foods & Food Ingredients Journal of Japan (2007) 212(5), 345-356.

  ・6) Tohda C., Komatsu K. and Kuboyama T. Scientific basis for the anti-dementia drugs of constituents from Ashwagandha (Withania somnifera). (2005) 和漢医薬学雑誌 22(Suppl.1), 176-182.

  ・ Tohda C., Kuboyama T. and Komatsu K. Search for natural products related to regeneration of the neuronal network. (2005) Neurosignals 14(1-2), 34-45.

  ・ Komatsu K., Tohda C. and Zhu S. Ginsengs Drugs - Molecular and chemical characteristics and possibility as antidementia drugs. (2005) Current topics in Nutraceutical Research 3(1), 47-65.

  ・ 東田千尋,カレースパイス成分のクルクミンがアルツハイマー痴呆を予防する(2002)ファルマシア 38(9), 891-892.

  ・ 東田千尋,　肝障害のかゆみとオピオイド (2001)　医学のあゆみ　197(8), 616-617.

  ・ 東田千尋, 小松かつ子, 中村憲夫, 服部征雄, コーヒー成分トリゴネリンは脳神経ネットワーク再構築を促すか？−抗痴呆薬開発への可能性を探る− (2001) 食品工業 44, 27-32.

  ・ 東田千尋,　カプサイシン受容体 (2000) Clinical Neuroscience 18, 610-611.

   

   

  著書

• ・ 東田千尋, , アルツハイマー病に有効な漢方処方：帰脾湯．漢方薬・生薬薬剤師講座テキスト　財団法人　日本薬剤師研修センター　(2010)　　4, 81-94.

  ・ 東田千尋, 小松かつ子,　中村憲夫,　服部征雄 認知症に対するコーヒーの作用．(2006) コーヒーの科学と機能 pp.50 - 58. アイ・ケイコーポレーション　

  ・ 小松かつ子,　東田千尋, 民族薬物の謎：世界の人参を追って．(2005) 薬用植物・生薬開発の新展開 New Development of Medical Plant pp302-324. シーエムシー

  ・ 小松かつ子,　東田千尋, 民族薬物の謎を追って．(2001) 薬用植物・生薬開発の最前線 Remarkable advance of Medicinal Plant pp278-298. シーエムシー

  ・ Jacobowitz D.M., Abbott L.C., Kallarakal A.T., Tohda C., Lau F.C. and Gillespie J.W. (2000) Normal brain development and gene discovery in the embryo. Pathology of Genetically Engineered Mice. pp123-134. Iowa State University Press

  ・ 東田道久、東田千尋、野村靖幸、Oocyteへの遺伝子導入と遺伝子解析. (2000) 廣川ニューロサイエンス第３巻「新しい神経伝達研究法〔�U〕」　pp 157-167. 廣川書店

  ・ 森望、東田千尋、野村靖幸, GAP-43 (growth associated protein-43), (1997) ノックアウトマウス・データブック　 pp 92-193. 中山書店

  ・ 東田千尋、野村靖幸、GAP-43 (B-50, growth associated protein), (1995) 広川タンパク質化学第9巻　脳・神経タンパク質、接着タンパク質　野村靖幸編　pp 211-217.　廣川書店

   

  翻訳

  ・ 東田千尋,　倉石泰,　植物性薬品(生薬)と栄養補助食品(サプリメント)　 (2009) カッツング薬理学 原書10版, 柳澤輝行, 飯野正光, 丸山敬, 三澤美和 監訳　pp.1161-1173.丸善

  ・ 東田千尋,　倉石泰,　植物性薬品(生薬)と栄養補助品(サプリメント)　 (2005) カッツング薬理学 原書9版, 柳澤輝行, 飯野正光, 丸山敬, 三澤美和 監訳　pp. 丸善

  ・ 東田千尋,　倉石泰,　 植物性薬品(生薬)と栄養補助品(サプリメント)　 (2002) カッツング薬理学 原書8版, 柳澤輝行, 飯野正光, 丸山敬, 三澤美和 監訳　pp1209-1226. 丸善