Research area

Division of Presymptomatic Disease Unit

Outline of the research

The pre-disease state, which is known as Mibyou in traditional Japanese medicine (Kampo medicine), is an Oriental medical concept and has not yet been scientifically understood. In collaboration with our division and Research Center for Pre-Disease Science, University of Toyama, we are conducting research to scientifically detect the Mibyou state by analyzing the fluctuation and expression change of biometric information such as genes, proteins, and behavior during the onset process, and to clarify the biological meaning of this state. There have been marked increases in the incidence of complex diseases, such as metabolic syndrome, and it is hard to treat them using only modern medical drugs. In contrast to the symptomatic treatments offered by modern medical drugs at the disease state, drugs targeting Mibyou may have great potential advantages as preventive and preemptive medicine. Therefore, we will work on the development of the drug treatment for Mibyou, and consequently the novel medical strategies.

Research Projects

  1. Deepening of biology for the pre-disease state (Mibyou).
    1. Understanding of the fluctuation of biometric information and its medical applications.
  2. Drug development for the pre-disease state (Mibyou).
    1. Development of the glutaminase inhibitor and its medical applications.
    2. Elucidation of the function of immunostimulatory nanoparticles (Nanosome) and nucleotide degradant (BIND) discovered by traditional Japanese medicine (Kampo formula) and their medical application.
    3. Elucidation of the function of immunostimulatory nanoparticles (Nanosome) and nucleotide degradant (BIND) discovered by traditional Japanese medicine (Kampo formula) and their medical application.
    4. Elucidation of the pathological mechanism and the search for new seeds of medicine for medical applications in enteric immune diseases.

Researcher in charge