Araki Masaya Specially Appointed Assistant Professor
Araki Masaya
AffiliationDivision of Complex Biosystem Research, Department of Research and Development
Research fieldsMetabolism, Food biochemistory
Campus careerPh.D. (Medical Sciences)
Biography University of Toyama Faculty Research Profiles
Education
2017, Department of Agricultural Chemistry, School of Agriculture, Meiji University
2019, Medical sciences, graduate school of comprehensive human sciences, University of Tsukuba
2023, Clinical sciences, graduate school of comprehensive human sciences, University of Tsukuba
Job career
2021, Research Fellow, Japan Society for the Promotion of Science, University of Tsukuba
2023, Specially Appointed Assistant Professor , Institute of Natural Medicine, University of Toyama
Research theme
Department
Division
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Project
Outline of the research
The major functions of lipids in the body are represented by components of biological membranes, energy storage, bioactive substances and biological barriers. These important functions are maintained through strict regulation of lipid metabolism including synthesis, degradation and remodeling at the transcriptional level by various transcription factors. Therefore, abnormalities in the regulation of lipid metabolism often involving dysfunction of these transcription factors can lead to diseases such as lifestyle-related diseases. So we are investigating the relationship between changes in lipid metabolism and pathogenesis caused by dysfunction of transcription factors using various genetically modified mice.
In particular, I am focusing on the transcription factors Sterol regulatory element binding protein (SREBP) which plays a crucial role in the transcriptional regulation of lipid synthesis and cAMP responsive element binding protein H (CREBH) which plays a crucial role in the transcriptional regulation of lipid degradation and conducting analysis in the intestine and liver. Furthermore, we would like to search for Kampo and food functional ingredients that regulate the activity of these transcription factors and enable the management of lipids in vivo for the treatment of diseases.
Thoughts on research
Eating is not only an essential activity for human survival, but also something that enriches our minds. However, in the treatment of lifestyle-related diseases caused by nutritional imbalances, dietary restrictions are often necessary. I want to contribute to the creation of innovative prevention and treatment methods for lifestyle-related diseases that allow people to enjoy various delicious foods from around the world for longer periods of time.
Paper
Araki M, Nakagawa Y, Saito H, Yamada Y, Han SI, Mizunoe Y, Ohno H, Miyamoto T, Sekiya M, Matsuzaka T, Sone H, Shimano H. Hepatocyte- or macrophage-specific SREBP-1a deficiency in mice exacerbates methionine- and choline-deficient diet-induced nonalcoholic fatty liver disease. Am J Physiol Gastrointest Liver Physiol. 2022
Nakagawa Y, Kumagai K, Han SI, Mizunoe Y, Araki M, Mizuno S, Ohno H, Matsuo K, Yamada Y, Kim JD, Miyamoto T, Sekiya M, Konishi M, Itoh N, Matsuzaka T, Takahashi S, Sone H, Shimano H. Starvation-induced transcription factor CREBH negatively governs body growth by controlling GH signaling. FASEB J. 2021
Nakagawa Y, Wang Y, Han SI, Okuda K, Oishi A, Yagishita Y, Kumagai K, Ohno H, Osaki Y, Mizunoe Y, Araki M, Murayama Y, Iwasaki H, Konishi M, Itoh N, Matsuzaka T, Sone H, Yamada N, Shimano H. Enterohepatic Transcription Factor CREB3L3 Protects Atherosclerosis via SREBP Competitive Inhibition. Cell Mol Gastroenterol Hepatol. 2021
Satoh A, Han SI, Araki M, Nakagawa Y, Ohno H, Mizunoe Y, Kumagai K, Murayama Y, Osaki Y, Iwasaki H, Sekiya M, Konishi M, Itoh N, Matsuzaka T, Sone H, Shimano H. CREBH Improves Diet-Induced Obesity, Insulin Resistance, and Metabolic Disturbances by FGF21-Dependent and FGF21-Independent Mechanisms. iScience. 2020
Araki M, Nakagawa Y, Oishi A, Han SI, Wang Y, Kumagai K, Ohno H, Mizunoe Y, Iwasaki H, Sekiya M, Matsuzaka T, Shimano H. The Peroxisome Proliferator-Activated Receptor α (PPARα) Agonist Pemafibrate Protects against Diet-Induced Obesity in Mice. Int J Mol Sci. 2018
keyword
Metabolic syndrome、Fatty acids、Intestinal stem cell、Transcription facror、SREBP、CREBH
