KODAMA Takeshi Assistant Professor
AffiliationLaboratory of Natural Products Chemistry, Section of Natural Products & Drug Discovery, Division of Medicinal Resources, Department of Research and Development
Research fieldsNatural Products Chemistry
Biography Academic Research Staff
2007 B.S., Department of Chemistry, Osaka City University, Japan
2009 M.S., Department of Chemistry, Osaka City University, Japan
2012 Ph.D., Department of Chemistry, Osaka City University, Japan
2013 Postdoctoral Fellow, Graduate School of Sience, Osaka City University, Japan
2013 Postdoctoral Fellow, Institute of Natural Medicine, University of Toyama, Japan
2016 Assistant Professor, Institute of Natural Medicine, University of Toyama, Japan
2017 Assistant Professor, National Institute of Technology, Akita College, Japan
2019 Assistant Professor, Institute of Natural Medicine, University of Toyama, Japan
Outline of the research
Natural products are secondary metabolites that are produced by plants and microorganisms. Due to their structural diversity and various biological activities, natural products have become the basis for developments of new agents for pharmaceutical and agricultural uses. In addition to nature, the complex chemical structure of natural products can be generated via organic synthetic and manipulation of the biosynthetic pathway. Currently, we are working on generating useful natural compounds from plants and microorganisms for development of seed drugs by combining organic synthesis, molecular biology and enzyme bioengineering. Hence, I focus on:
1）Constructing library of natural compounds and their derivatives
2）Generating natural and non-natural compounds using enzymes with high substrate promiscuity
Thoughts on research
What attracts me to the field of natural product chemistry is the complex chemicals structure that are produced by nature. I am intrigued on how to generate these chemical structures by organic synthesis, and wonder how the difference in the chemical structures will affect their biological activities. Ever since I started my research, my research interest has since grown to many areas. I hope to combine the fields that I am interested in to produce new discovery in the field of natural product chemistry.
Win, N.N., Kodama, T., Lae, K.Z.W., Win, Y.Y., Ngwe, H., Abe, I., Morita, H. Bis-iridoid and iridoid glycosides: Viral protein R inhibitors from Picrorhiza kurroa collected in Myanmar. Fitoterapia, 134, 101-107 (2019).
Matsui, T., Kodama, T., Mori, T., Tadakoshi, T., Noguchi, H., Abe, I., Morita, H. 2-Alkylquinolone alkaloid biosynthesis in the medicinal plant Evodia rutaecarpa involves collaboration of two novel type III polyketide synthases. J. Biol. Chem., 292, 9117-9135 (2017).
Kodama, T., Ito, T., Dibwe, D. F., Woo, S., Morita, H. Syntheses of benzophenone-xanthone hybrid polyketides and their antibacterial activities. Bioorg. Med. Chem. Lett., 27, 2397-2400 (2017).
Yang, X., Matsui, T., Kodama, T., Mori, T., Zhou, X., Taura, F., Noguchi, H., Abe, I., Morita, H. Structural basis for olivetolic acid formation by a polyketide cyclase from Cannabis sativa. FEBS J., 283, 1088-1106 (2016).
Duc, V. H., Kodama, T., Hien, T. B. L., Kiem, V. P., Thao, T. D., Tai, H. B., Anh, T. L., Win, N. N., Imagawa, H., Ito, T., Morita, H., Hoai, T. N. A new polyoxygenated cyclohexene and a new megastigmane glycoside from Uvaria grandiflora. Bioorg. Med. Chem. Lett., 25, 3246-3250 (2015).
Natural product chemistry, Organic synthesis, Enzyme engineering