Maneenet Juthamart Specially Appointed Assistant Professor
Maneenet Juthamart
AffiliationNatural Drug Discovery Lab, Section of Natural Products & Drug Discovery, Division of Medicinal Resources, Department of Research and Development
Research fieldsNatural Product Chemistry
Campus careerPh.D. (Research and Development in Pharmaceuticals)
Biography University of Toyama Faculty Research Profiles
Education
2014 January, B.Sc. (Medical Science) Faculty of Medical Science, Naresuan University, Thailand
2016 October, M.Sc. (Pharmaceutical Chemistry and Natural Products) Faculty of Pharmaceutical Sciences, Khon Kaen University, Thailand
2021 June, Ph.D.(Research and Development in Pharmaceuticals) Faculty of Pharmaceutical Sciences, Khon Kaen University, Thailand
Job career
2019 August - 2020 November, Student research, Institute of Natural Medicine, University of Toyama
2021 June, Researcher, Faculty of Pharmaceutical Sciences, Khon Kaen University, Thailand
2021 December, Postdoctoral Fellow, Institute of Natural Medicine, University of Toyama
2023 April, Visiting Researcher, Institute of Natural Medicine, University of Toyama (supported by Khon Kaen University)
2024 April, Postdoctoral Fellow, Institute of Natural Medicine, University of Toyama
2025 April, Specially Appointed Assistance Professor, Natural Drug Discovery Lab, Institute of Natural Medicine, University of Toyama
Research theme
Department
Division
Section
Project
Outline of the research
My research sits at the interface of chemistry and biology, focusing on the discovery of bioactive natural products from medicinal plants worldwide. By employing advanced analytical techniques such as NMR spectroscopy, mass spectrometry, and a combination of in vitro and in vivo biological assays, I aim to identify novel compounds with therapeutic potential. My current work targets the adaptive mechanisms of cancer cells, including their ability to metastasize, survive in hostile microenvironments, evade immune surveillance, adaptation to nutrient deprivation, regulate autophagy, and thrive under hypoxic conditions. Through experimentation, I strive to develop next-generation anticancer agents that are potent and mechanistically distinct therapeutics that not only suppress tumor progression, but also redefine strategies for overcoming cancer resistance.
Thoughts on research
I dive into my research with a smile, trusting that hard work and a steady spirit can uncover something truly good for people everywhere
Paper
Nelumbo nucifera petals ameliorate depressive-like symptoms and cognitive deficit in unpredictable chronic mild stress mouse model
J. Maneenet, Y. Chotritthirong, A.M. Omar, R. Choonong, S. Daodee, O. Monthakantirat , C. Khamphukdee, S. Pitiporn, S. Awale, K. Matumoto, Y. Chulikhit
Nutrient, 2024.17, 942024.
Droserone and dioncoquinone B, and related naphthoquinones as potent antiausterity agents against human PANC-1 pancreatic cancer cells
J. Maneenet, N. Tajuddeen, H.H.Nguyen, R. Fujii, B.K. Lombe, D. Feineis, S. Awale, G. Bringmann
Results in Chemistry, 2024, 7, 101352.
Chemical constituents of Callistemon subulatus and their anti-pancreatic cancer activity against human PANC-1 cell line
J. Maneenet, A.M. Tawila, A.M. Omar, N.D. Phan, C. Ojima, M. Kuroda, M. Sato, M. Mizoguchi, I. Takahashi, S. Awale
Plants, 2022, 11, 2466.
Merging the multi-target effects of Kleeb Bua Daeng, a Thai traditional herbal formula in unpredictable chronic mild stress-induced depression
J. Maneenet, O. Monthakantirat, S. Daodee, C. Boonyarat, Y. Chotritthirong, P. Kwankhao, S. Pitiporn, S. Awale, Y. Chulikhit
Pharmaceuticals, 2021, 14, 659.
Benzylisoquinoline alkaloids from Nelumbo nucifera Gaertn. petals with antiausterity activities against the HeLa human cervical cancer cell line
J. Maneenet, A.M. Omar, S. Sun, M. Kim, S. Daodee, O. Monthakantirat, C. Boonyarat, Y. Chulikhit, S. Awale
Zeitschrift fur Naturforschung C, 2021, 76, 401 - 406.
keyword
Drug discovery、Natural product chemisty、Cancer research、Hypoxia、Nutrient deprivation、Autophagy
