Nakagawa Yoshimi Professor
Nakagawa Yoshimi
AffiliationDivision of Complex Biosystem Research, Department of Research and Development
Research fieldsMetabolism
Campus careerPh.D. (Agriculture)
Biography University of Toyama Faculty Research Profiles
Education
Tokyo University of Science
Graduate School of Agriculture, University of Tsukuba
Job career
Assistant professor, TARA Center, University of Tsukuba
Associate professor, International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba
Professor, Institute of Natural Medicine, University of Toyama
Research theme
Department
Division
Section
Project
Outline of the research
Lifestyle-related diseases are at the center of health problems in Japanese society. When the deterioration of the pathological condition worsens, it progresses to a condition leading to death such as cardiovascular disease and cancer. The origin of the lifestyle-related disease is an abnormality in nutrition metabolism. It is necessary to elucidate the abnormality at the molecular level in order to construct a new treatment strategy for lifestyle-related diseases. In the development of lifestyle-related diseases, the imbalance between absorption and consumption of nutrients promotes excessive nutritional accumulation in the body and causes obesity. Therefore, it is necessary to consider the pathological condition from nutrient absorption from the small intestine, nutrient metabolism in the liver, and nutrient accumulation in peripheral tissues including adipose tissue. From this point of view, we focus on transcription factors that regulate gene expression. Among many transcription factors that regulate the expression of genes involved in nutrient metabolism, Cyclic AMP Response Element-binding Protein H (CREBH), which functions to improve lipid metabolism, and conversely, the worsening Sterol regulatory element-binding protein (SREBP), We are mainly analyzing the regulation of nutrient metabolism by crosstalk between transcription factors. Using genetically modified mice, we aim to elucidate the molecular mechanism of pathology by using analytical techniques from the cell level to the mouse level. In addition, we will develop treatment strategies to improve lifestyle-related diseases from Kampo and diet.
Thoughts on research
In Japan, which has entered an aging society, the number of patients with lifestyle-related diseases is expected to increase. Therefore, urgent understanding of the disease is necessary. By comprehensively analyzing and understanding the disease, prevention and treatment will be possible. Lifestyle-related diseases have been studied for a long time, but they have not been overcome yet. In order to overcome it, we will discover new discoveries and aim to overcome lifestyle-related diseases through "Challenging research" and "Collaboration with many researchers in and outside of Japan including Toyama University".
Paper
A pontine-medullary loop crucial for REM sleep and its deficit in Parkinson's disease. Kashiwagi M, Beck G, Kanuka M, Arai Y, Tanaka K, Tatsuzawa C, Koga Y, Saito YC, Takagi M, Oishi Y, Sakaguchi M, Baba K, Ikuno M, Yamakado H, Takahashi R, Yanagisawa M, Murayama S, Sakurai T, Sakai K, Nakagawa Y, Watanabe M, Mochizuki H, Hayashi Y. Cell. 187(22):6272-6289. 2024年
Oxysterol binding protein regulates the resolution of TLR-induced cytokine production in macrophages. Diercks AH, Podolskaia IS, Murray TA, Jahn AN, Mai D, Liu D, Amon LM, Nakagawa Y, Shimano H, Aderem A, Gold ES. Proc Natl Acad Sci U S A. 121(33):e2406492121. 2024年
Wogonin, a compound in Scutellaria baicalensis, activates ATF4–FGF21 signaling in mouse hepatocyte AML12 cells. Yamada Y, Saito H, Araki M, Tsuchimoto Y, Muroi SI, Suzuki K, Toume K, Kim JD, Matsuzaka T, Sone H, Shimano H, Nakagawa Y. Nutrients 14(19):3920. 2022年
Enterohepatic Transcription Factor CREB3L3 Protects Atherosclerosis via SREBP Competitive Inhibition. Nakagawa Y, Wang Y, Han S-I, Okuda K, Oishi A, Yagishita Y, Kumagai K, Ohno H, Osaki Y, Mizunoe Y, Araki M, Murayama Y, Iwasaki H, Konishi M, Itoh N, Matsuzaka T, Sone H, Yamada N, Shimano H. Cell Mol Gastroenterol Hepatol. 11(4):949-971. 2021年
TFE3 transcriptionally activates hepatic IRS-2, participates in insulin signaling and ameliorates diabetes. Nakagawa Y, Shimano H, Yoshikawa T, Ide T, Tamura M, Yamamoto T, Inoue N, Matsuzaka T, Takahashi A, Hasty AH, Suzuki H, Sone H, Toyoshima H, Yahagi N, Yamada N. Nat Med. 12(1):107-113. 2006年
keyword
Metabolic syndrome, Hyperlipidemia, Gene expression, Genetically modified mice, CREBH - FGF21, SREBP
