Biography Academic Research Staff
Tokyo University of Science
Graduate School of Agriculture, University of Tsukuba
Assistant professor, TARA Center, University of Tsukuba
Associate professor, International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba
Professor, Institute of Natural Medicine, University of Toyama
Outline of the research
Lifestyle-related diseases are at the center of health problems in Japanese society. When the deterioration of the pathological condition worsens, it progresses to a condition leading to death such as cardiovascular disease and cancer. The origin of the lifestyle-related disease is an abnormality in nutrition metabolism. It is necessary to elucidate the abnormality at the molecular level in order to construct a new treatment strategy for lifestyle-related diseases. In the development of lifestyle-related diseases, the imbalance between absorption and consumption of nutrients promotes excessive nutritional accumulation in the body and causes obesity. Therefore, it is necessary to consider the pathological condition from nutrient absorption from the small intestine, nutrient metabolism in the liver, and nutrient accumulation in peripheral tissues including adipose tissue. From this point of view, we focus on transcription factors that regulate gene expression. Among many transcription factors that regulate the expression of genes involved in nutrient metabolism, Cyclic AMP Response Element-binding Protein H (CREBH), which functions to improve lipid metabolism, and conversely, the worsening Sterol regulatory element-binding protein (SREBP), We are mainly analyzing the regulation of nutrient metabolism by crosstalk between transcription factors. Using genetically modified mice, we aim to elucidate the molecular mechanism of pathology by using analytical techniques from the cell level to the mouse level. In addition, we will develop treatment strategies to improve lifestyle-related diseases from Kampo and diet.
Thoughts on research
In Japan, which has entered an aging society, the number of patients with lifestyle-related diseases is expected to increase. Therefore, urgent understanding of the disease is necessary. By comprehensively analyzing and understanding the disease, prevention and treatment will be possible. Lifestyle-related diseases have been studied for a long time, but they have not been overcome yet. In order to overcome it, we will discover new discoveries and aim to overcome lifestyle-related diseases through "Challenging research" and "Collaboration with many researchers in and outside of Japan including Toyama University".
Enterohepatic Transcription Factor CREB3L3 Protects Atherosclerosis via SREBP Competitive Inhibition. Nakagawa Y, Wang Y, Han S-I, Okuda K, Oishi A, Yagishita Y, Kumagai K, Ohno H, Osaki Y, Mizunoe Y, Araki M, Murayama Y, Iwasaki H, Konishi M, Itoh N, Matsuzaka T, Sone H, Yamada N, Shimano H. Cell Mol Gastroenterol Hepatol. 11(4):949-971. 2020年
CREBH Improves Diet-Induced Obesity, Insulin Resistance, and Metabolic Disturbances by FGF21-Dependent and FGF21-Independent Mechanisms. Satoh A, Han SI, Araki M, Nakagawa Y (Correspondence), Ohno H, Mizunoe Y, Kumagai K, Murayama Y, Osaki Y, Iwasaki H, Sekiya M, Konishi M, Itoh N, Matsuzaka T, Sone H, Shimano H. iScience. 23(3):100930. 2020年
Epigenetic modulation of Fgf21 in the perinatal mouse liver ameliorates diet-induced obesity in adulthood. Yuan X, Tsujimoto K, Hashimoto K, Kawahori K, Hanzawa N, Hamaguchi M, Seki T, Nawa M, Ehara T, Kitamura Y, Hatada I, Konishi M, Itoh N, Nakagawa Y, Shimano H, Takai-Igarashi T, Kamei Y, Ogawa Y. Nat Commun. 9(1):636. 2018年
TGF-beta activates Akt kinase through a microRNA-dependent amplifying circuit targeting PTEN. Kato M, Putta S, Wang M, Yuan H, Lanting L, Nair I, Gunn A, Nakagawa Y, Shimano H, Todorov I, Rossi JJ, Natarajan R. Nat Cell Biol. 11(7):881-9. 2009
TFE3 transcriptionally activates hepatic IRS-2, participates in insulin signaling and ameliorates diabetes. Nakagawa Y, Shimano H, Yoshikawa T, Ide T, Tamura M, Furusawa M, Yamamoto T, Inoue N, Matsuzaka T, Takahashi A, Hasty AH, Suzuki H, Sone H, Toyoshima H, Yahagi N, Yamada N. Nat Med. 2006 12(1):107-13. 2006
Metabolic syndrome, Hyperlipidemia, Gene expression, Genetically modified mice, CREBH - FGF21, SREBP