Reserchers

YANG Ximeng Assistant Professor

YANG Ximeng

AffiliationLaboratory of Neuromedical Science, Section of Neuromedical Science, Division of Bioscience, Department of Research and Development

Research fieldsNeuropharmacology, Neuroscience

Campus careerBachelor of Pharmacy

Biography Academic Research Staff

Education

Apr 2011-Mar 2017 University of Toyama (Department of Pharmacy)
Apr 2017-Nov 2017 University of Toyama (Doctor Course of Pharmaceutical Science)

Job career

Dec 2017- Specially Appointed Assistant Professor (Institute of Natural Medicine, University of Toyama)
Apr 2020- Assistant Professor (Institute of Natural Medicine, University of Toyama)

Research theme

Department

Division

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Project

Outline of the research

My research theme is to establish novel therapeutic strategies for neurodegenerative diseases and aging-related diseases, such as Alzheimer’s disease and Frailty. Especially, I'm focusing on natural medicines which reconstruct neural networks in central and peripheral nervous systems. From pharmacological studies of the effective drugs and natural components, I aim to clarify comprehensive molecular mechanisms for restoring the degenerated neural circuits, and to find novel phenomena in neuroscience.

Thoughts on research

In recent aging society, no drug succeeded to achieve sufficient functional recovery for neurodegenerative diseases, such as Alzheimer's disease. Although it has been generally thought that neural circuits in central nervous system have no capacity to regenerate anymore, I previously found several effective natural medicines reconstruct neural circuits in the brain and recover memory function.Therefore, I aim to establish novel promising therapeutic strategies for overcoming these diseases, and contribute to human health through pharmacological and neuroscientific approaches of natural medicines.

Paper

Diosgenin restores Aβ-induced axonal degeneration by reducing the expression of heat shock cognate 70 (HSC70).
Yang X, Tohda C.
Scientific Report 8 ( 1 ) 11707 2018.08
Joint Work

Heat Shock Cognate 70 Inhibitor, VER-155008, Reduces Memory Deficits and Axonal Degeneration in a Mouse Model of Alzheimer’s Disease
Yang X, Tohda C.
Frontiers in Pharmacology 9 48 2018.01
Joint Work

Diosgenin-rich yam extract enhances cognitive function: a placebo-controlled, randomized, double-blind, crossover study of healthy adults
Tohda C, Yang X, Matsui M, Inada Y, Kadomoto E, Nakada S, Watari H, Shibahara N.
Nutrients 9(10) 1160 2017.10
Joint Work

keyword

Alzheimer's disease, Dementia, Frailty, Neural network reconstruction, Memory recovery