Manse Yoshiaki Associate Professor
Yoshiaki Manse
AffiliationDepartment of Medicinal Resources Management
Research fieldsNatural Products Chemistry
Campus careerPh.D.（Pharmaceutical Science）
Biography University of Toyama Faculty Research Profiles
Education
Mar. 2006 B.S., Faculty of Pharmacy, Kindai University, Japan
Mar. 2008 M.S., Faculty of Pharmacy, Kindai University, Japan
Dec. 2018 Ph.D., Faculty of Pharmacy, Kindai University, Japan
Job career
Apr. 2008 researcher, Kaminomoto Ltd.
Sep. 2021 lecturer, Pharmaceutical Research and Technology Institute, Kindai University, Japan
Mar. 2025 Associate Professor, Institute of Natural Medicine, University of Toyama
Research theme
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Outline of the research
The research is based on the isolation and structural analysis of bioactive components using natural resources, and exploratory research for pharmaceutical and cosmetic materials. In nature, there are natural products that show diverse structures that humans cannot conceive of, and people have isolated them, determined their structures and discovered numerous compounds so far. Some of these have become indispensable for the development of health and public health, such as being used clinically as medicines, and even today the chemical structure of natural products occupies an important position in the development of medicines. Furthermore, there are many scientifically unexplored natural resources in the world's folk and traditional medicines, whose functionality needs to be elucidated. We are targeting these natural resources and working on the following research themes.
1) Searching for new hair-growing and photo-ageing-preventive ingredients from Japanese folk medicine.
2) Elucidating the components of the world's unutilised resources.
3) Exploitation of new functionalities and elucidation of the mechanisms of action of underutilised resources.
Thoughts on research
I believe that "research is communication with nature." Humans cannot converse with nature, and cannot understand what nature is thinking. Thus, we humans have repeatedly tried and failed to understand nature through experience and research, and have passed on nature's messages to future generations in the form of research papers. I will ask nature, "What contributes to human health?" and use the language of "experiments" to sincerely seek answers from nature and pursue research that will enable me to convey that message.
Paper
Luo F., Manse Y., Ishikawa S., Nishi S., Chen A., Wang T., Morikawa T. Aromatase inhibitors isolated from a flowering tea, snow Chrysanthemum (the capitula of Coreopsis tinctoria Nutt.)., J. Nat. Med., 77(2), 387-396 (2023)
Luo F., Manse Y., Chaipech S., Pongpiriyadacha Y., Muraoka O., Morikawa T. Structures of Mammeasins P and Q, Coumarin-Related Polysubstituted Benzofurans, from the Thai Medicinal Plant Mammea siamensis (Miq.) T. Anders.: Anti-Proliferative Activity of Coumarin Constituents against Human Prostate Carcinoma Cell Line LNCaP., Pharmaceuticals, 16(2), 231 (2023).
Manse Y., Luo F., Kato K., Okazaki A., Okada-Nishida E., Yanagida M., Nakamura S., Morikawa T. Ent-kaurane-type diterpenoids from Isodonis Herba activate human hair follicle dermal papilla cells proliferation via the Akt/GSK-3β/β-catenin transduction pathway., J. Nat. Med., 75(2), 326-338 (2021).
Morikawa T., Manse Y., Luo F., Fukui H., Inoue Y., Kaieda T., Ninomiya K., Muraoka O., Yoshikawa M. Indole Glycosides from Calanthe discolor with Proliferative Activity on Human Hair Follicle Dermal Papilla Cells., Chem. Pharm. Bull., 69(5), 464-471 (2021).
Tanabe G., Manse Y., Ogawa T., Sonoda N., Marumoto S., Ishikawa F., Ninomiya K., Chaipech S., Pongpiriyadacha Y., Muraoka O., Morikawa T. Total Synthesis of γ-Alkylidenebutenolides, Potent Melanogenesis Inhibitors from Thai Medicinal Plant Melodorum fruticosum., J. Org. Chem., 83(15), 8250-8264 (2018).
keyword
natural products chemistry、MONOTORI science、Organic Structural Analysis、Natural medicine、Cosmetic Science、chemical biology
